Prof. Dr. Peter Hildebrandt

Research interests

Vibrational spectroscopy, photoreceptors, metalloenzymes, redox enzymes, spectroelectrochemistry, electron transfer, interfacial processes, photoinduced reactions

Research Fields in UniCat

Research Field E2
Research Field D3
Research Field E3
Research Field D4
Research Field E4

2007-2011: B1, B2, B3, B4, B5

Selection of research projects

UniCat publications

805 Coupling of Ci-VSP Modules Requires a Combination of Structure and Electrostatics within the Linker K. Hobiger, T. Utesch, M. A. Mroginski, T. Friedrich Biophysical Journal 2012, 102, 1313 - 1322, 10.1016/j.bpj.2012.02.027

800 Mapping local electric fields in proteins at biomimetic interfaces G. Schkolnik, T. Utesch, J. Salewski, K. Tenger, D. Millo, A. Kranich, I. Zebger, C. Schulz, L. Zimanyi, G. Rakhely, M. A. Mroginski, P. Hildebrandt Chemical Communications 2012, 48, 70 - 72, 10.1039/c1cc13186a

799 NAD(H)-coupled hydrogen cycling - structure-function relationships of bidirectional [NiFe] hydrogenases M. Horch, L. Lauterbach, O. Lenz, P. Hildebrandt, I. Zebger FEBS letters 2012, 586, 545 - 556, 10.1016/j.febslet.2011.10.010

780 Probing the origin of the metabolic precursor of the CO ligand in the catalytic center of [NiFe]-hydrogenase I. Bürstel, P. Hummel, E. Siebert, N. Wisitruangsakul, I. Zebger, B. Friedrich, O. Lenz Journal of Biological Chemistry 2011, 286, 44937 - 44944, 10.1074/jbc.M111.309351

778 Characterization and Crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression M. Mahro, C. Coelho, J. Trincao, D. Rodrigues, M. Terao, E. Garattini, M. Saggu, F. Lendzian, P. Hildebrandt, M. Romao, S. Leimkühler Drug Metabolism and Disposition 2011, 39, 1939 - 1945,

774 Insights into the structure of the active site of the O2-tolerant membrane-bound hydrogenase [NiFe] of R. eutropha H16 by molecular modeling Y. Rippers, T. Utesch, P. Hildebrandt, I. Zebger, M. A. Mroginski Physical Chemistry Chemical Physics 2011, 13, 16146 - 16149,

773 The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin 2 variant S. Bruun, H. Naumann, U. Kuhlmann, C. Schulz, K. Stehfest, P. Hegemann, P. Hildebrandt FEBS letters 2011, 585, 3998 - 4001,

772 The functional role of cytochrome b in the electron transfer pathway of the membrane bound hydrogenase from Re immobilized on electrodes M. Sezer, S. Frielingsdorf, D. Millo, I. Zebger, T. Utesch, M. A. Mroginski, N. Heidary, B. Friedrich, P. Hildebrandt, I. Weidinger Journal of Physical Chemistry B 2011, 115, 10368 - 10374,

760 [NiFe] and [FeS] Cofactors in the Membrane-Bound Hydrogenase of Ralstonia eutropha Investigated by X-ray Absorption Spectroscopy: Insights into O2-Tolerant H2 Cleavage F. Johannes, S. Löscher, O. Sanganas, E. Siebert, I. Zebger, M. Stein, M. Ludwig, A. L. De Lacey, H. Dau, B. Friedrich, O. Lenz, M. Haumann Biochemistry 2011, 50, 5858 - 5869, dx.doi.org/10.1021/bi200367u

577 A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase T. Goris, A. F. Wait, M. Saggu, J. Fritsch, N. Heidary, M. Stein, I. Zebger, F. Lendzian, F. A. Armstrong, B. Friedrich, O. Lenz Nature Chemical Biology 2011, 7, 310 - 318, 10.1038/NCHEMBIO.555

501 Elucidating photoinduced structural changes in phytochromes by the combined 3 application of resonance Raman spectroscopy and theoretical methods M. A. Mroginski, D. von Stetten, S. Kaminski, F. Velazquez Escobar, N. Michael, G. Daminelli-Widany, P. Hildebrandt Journal of Molecular Structure 2011, 993, 15 - 25, 10.1016/j.molstruc.2011.02.038

500 Electron Transfer of Proteins at Membrane Mo P. Hildebrandt, J. J. Feng, A. Kranich, H. K. Ly, M. Marti, D. F. Martin, D. H. Murgida, D. A. Paggi, N. Wisitruangsakul, M. Sezer, I. Weidinger, I. Zebger SERS - Analytical, Biophysical and Life Science Applications Sebastian Schlücker Wiley 2010, 0, 219 - 240,

499 Electric-field effects on the interfacial electron transfer and protein dynamics 3 of cytochrome c H. K. Ly, N. Wisitruangsakul, M. Sezer, J. J. Feng, A. Kranich, I. Weidinger, I. Zebger, D. H. Murgida, P. Hildebrandt Journal of Electroanalytical Chemistry 2011, 0, 0 - 0, 10.1016/j.jelechem.2010.12.020

498 Surface-enhanced vibrational spectroscopy for probing transient interactions of proteins with biomimetic interfaces: electric field effects on structure, dynamics and function of cytochrome c H. K. Ly, M. Sezer, N. Wisitruangsakul, J. J. Feng, A. Kranich, D. Millo, I. Weidinger, I. Zebger, D. H. Murgida, P. Hildebrandt FEBS Journal 2011, 278, 1382 - 1390, 10.1111/j.1742-4658.2011.08064.x

497 Structure of the Chromophore Binding Pocket in the Pr State of Plant Phytochrome phyA M. A. Mroginski, S. Kaminski, D. von Stetten, S. Ringsdorf, W. Gärtner, L. O. Essen, P. Hildebrandt Journal of Physical Chemistry B 2011, 115, 1220 - 1231,

496 SEIRA Spectroscopy of the Electrochemical Activation of an Immobilized [NiFe] Hydrogenase under Turnover and Non-Turnover Conditions D. Millo, P. Hildebrandt, M. E. Pandelia, W. Lubitz, I. Zebger Angewandte Chemie International Edition 2011, 50, 2632 - 2634, 10.1002/anie.201006646

495 In Situ Spectroelectrochemical Investigation of Electrocatalytic Microbial Biofilms by Surface-Enhanced Resonance Raman Spectroscopy D. Millo, F. Harnisch, S. A. Patil, H. K. Ly, U. Schröder, P. Hildebrandt Angewandte Chemie International Edition 2011, 50, 2625 - 2627,

494 Dinuclear Copper Complexes Based on Parallel ß-Diiminato Binding Sites and their Reactions with O2: Evidence for a Cu-O-Cu Entity P. Haack, C. Limberg, K. Ray, B. Braun, U. Kuhlmann, P. Hildebrandt, C. Herwig Inorganic Chemistry 2011, 50, 2133 - 2142, 10.1021/ic101249k

493 Induced SER-activity in nanostructured Ag-silica-Au Supports via Long Range Plasmon Coupling J. J. Feng, U. Gernert, P. Hildebrandt, I. Weidinger Advanced Functional Materials 2010, 20, 1954 - 1961,

492 Redox properties and catalytic activity of surface-bound human sulfite oxidase studied by a combined surface enhanced resonance Raman spectroscopic and electrochemical approach M. Sezer, R. Spricigo, T. Utesch, D. Millo, S. Leimkühler, M. A. Mroginski, U. Wollenberger, P. Hildebrandt, I. Weidinger Physical Chemistry Chemical Physics 2010, 12, 7894 - 7903,

491 Probing the active site of an oxygen-tolerant NAD+ reducing [NiFe] hydrogenase from Ralstonia eutropha H16 by in-situ EPR and FTIR spectroscopy M. Horch, L. Lauterbach, M. Saggu, O. Lenz, P. Hildebrandt, F. Lendzian, R. Bittl, Z. Ingo Angewandte Chemie International Edition 2010, 49, 8026 - 8029, 10.1002/anie.201002197

458 The Hydrogenase Subcomplex of the NAD+-Reducing [NiFe] Hydrogenase from Ralstonia eutropha - Insights into Catalysis and Redox Interconversions L. Lauterbach, J. Liu, M. Horch, P. Hummel, A. Schwarze, M. Haumann, K. A. Vincent, O. Lenz, I. Zebger European Journal of Inorganic Chemistry 2011, 7, 1067 - 1079, 10.1002/ejic.201001053

445 Mesoporous indium tin oxide as a novel platform for bioelectronics S. Frasca, T. von Graberg, J. Feng, A. Thomas, B. Smarsly, I. Weidinger, F. Scheller, P. Hildebrandt, U. Wollenberger ChemCatChem 2010, 2, 839 - 845, 10.1002/cctc.201000047

444 Functionalized Ag nanoparticles with tunable optical properties for selective protein analysis A. Sivanesan, H. K. Ly, J. Kozuch, M. Sezer, U. Kuhlmann, A. Fischer, I. M. Weidinger Chemical Communications 2011, 47, 3553 - 3555, 10.1039/C0CC05058J

421 Protein complex formation affects the Ni-Fe and Fe-S centers of H2-sensing regulatory hydrogenase from Ralstonia eutropha H16 S. Löscher, A. Gebler, M. Stein, O. Sanganas, T. Buhrke, I. Zebger, H. Dau, B. Friedrich, M. Haumann ChemPhysChem 2010, 11, 1297 - 1306, 10.1002/cphc.200901007

394 Overexpression,isolation and spectroscopic characterization of the bidirectional [NiFe]-hydrogenase from Synechocystis sp. PCC 6803 F. Germer, I. Zebger, M. Saggu, F. Lendzian, R. Schulz, J. Appel The Journal Of Biological Chemistry 2009, 284, 36462 - 36472, 10.1074/jbc.M109.028795

381 Protein complex formation affects the Ni-Fe and Fe-S centers of H2-sensing regulatory hydrogenase from Ralstonia eutropha H16 M. Stein, A. Gebler, S. Löscher, O. Sanganas, T. Buhrke, I. Zebger, H. Dau, B. Friedrich, O. Lenz, M. Haumann ChemPhysChem 2010, 11, 1297 - 1306, 10.1002/cphc.200901007

349 Impact of amino acid substitutions near the catalytic site on the spectral properties of an O2-tolerant membrane-bound [NiFe]-hydrogenase M. Saggu, M. Ludwig, B. Friedrich, P. Hildebrandt, R. Bittl, F. Lendzian, O. Lenz, I. Zebger ChemPhysChem 2010, 11, 1215 - 1224, 10.1002/cphc.200900988

345 Comparison of the membrane-bound [NiFe] hydrogenases from R. eutropha H16 and D. vulgaris Miyazaki F in the oxidized ready state by pulsed EPR M. Saggu, C. Teutloff, M. Ludwig, M. Brecht, M. E. Pandelia, O. Lenz, B. Friedrich, W. Lubitz, P. Hildebrandt, F. Lendzian, R. Bittl Physical Chemistry Chemical Physics 2010, 12, 2139 - 2148, 10.1039/b922236g

342 On the Distance Dependent Electron Transfer Rate of Immobilized Redox Proteins - A Statistical Physics Approach, S. Georg, J. Kabuss, I. M. Weidinger, D. H. Murgida, P. Hildebrandt, A. Knorr, M. Richter Phys. Rev. E: Stat. Phys. Plasmas Fluids Relat. Interdisciplin. Top. 2010, 81, 46101 - 46111, 10.1103/PhysRevE.81.046101

333 Theory of time-resolved Raman scattering and fluorescence emission from semiconductor quantum dots J. Kabuss, S. Werner, A. Hoffmann, P. Hildebrandt, A. Knorr, M. Richter Physical Review B 2010, 81, 75314 - 0, 10.1103/PhysRevB.81.075314

332 Image dipoles approach to the local field enhancement in nanostructured Ag-Au hybrid devices C. David, M. Richter, A. Knorr, I. M. Weidinger, P. Hildebrandt The Journal of Chemical Physics 2010, 132, 24712 - 0, 10.1063/1.3291438

331 Molecular basis of coupled protein and electron transfer dynamics of cytochrome c in biomimetic complexes D. A. Paggi, D. F. Martin, P. M. De Biase, P. Hildebrandt, M. A. Marti, D. H. Murgida Journal of the American Chemical Society 2010, 132, 5769 - 5778, 10.1021/ja910707r

330 Electrosynthesis of SER-active silver nanopillar electrode arrays J. Feng, U. Gernert, P. Hildebrandt, D. H. Murgida Journal of Physical Chemistry C 2010, 114, 7280 - 7284, 10.1021/jp9084469

329 Molecular Basis for the Electric Field Modulation of cytochrome c Structure and Function P. M. De Biase, D. A. Paggi, F. Doktorovich, P. Hildebrandt, D. A. Estrin, D. H. Murgida, M. A. Marti Journal of the American Chemical Society 2009, 131, 16248 - 16256, 10.1021/ja906726n

286 The anomaly of the nu-1 resonance Raman band of beta-carotene in solution and in photosystems I and II N. Tschirner, M. Schenderlein, A. Zouni, E. Schlodder, M. A. Mroginski, P. Hildebrandt, C. Thomsen Physica Status Solidi B-Basic Solid State Physics 2009, 246, 2790 - 2793, 10.1002/pssb.200982299

285 Vibrational Raman Spectra from the Self Consistent Charge Density Functional Tight Binding Method via classical Time-correlation functions S. Kaminski, M. Gaus, P. Phatak, D. von Stetten, M. Elstner, M. A. Mroginski Journal of Chemical Theory and Computation 2010, 6, 1240 - 1255, 10.1021/ct900660x

283 Resonance Raman spectra of beta-carotene in solution and in photosystems revisited: an experimental and theoretical study N. Tschirner, M. Schenderlein, K. Brose, E. Schlodder, M. A. Mroginski, C. Thomsen, P. Hildebrandt Physical Chemistry Chemical Physics 2009, 11, 11471 - 11478, 10.1039/b917341b

280 Spectroelectrochemical Study of the [NiFe] Hydrogenase from Desulfovibrio vulgaris Miyazaki F in Solution and immobilized on biocompatible Gold surfaces D. Millo, M. E. Pandelia, T. Utesch, N. Wisitruangsakul, M. A. Mroginski, W. Lubitz, P. Hildebrandt, I. Zebger Journal of Physical Chemistry B 2009, 113, 15344 - 15351, 10.1021/jp906575r

133 Concerted action of two novel auxiliary proteins in assembly of the active site in a membrane-bound [NiFe]-hydrogenase M. Ludwig, T. Schubert, I. Zebger, N. Wisitruangsakul, M. Saggu, A. Strack, O. Lenz, P. Hildebrandt, B. Friedrich The Journal Of Biological Chemistry 2009, 284, 2159 - 2168, 10.1074/jbc.M808488200

61 Resonanz-Raman-spektroskopische Untersuchung der Chromophorheterogeneität und Photokonversion von Phytochromkristallen und -lösungen D. von Stetten, M. Günther, P. Scheerer, D. H. Murgida, M. A. Mroginski, N. Krauss, T. Lamparter, J. Zhang, D. M. Anstrom, R. D. Vierstra, K. T. Forest, P. Hildebrandt Angewandte Chemie 2008, 120, 4831 - 4833, 10.1002/ange.200705716

60 Chromophore heterogeneity and photoconversion in phytochrome crystals and solutions studied by resonance Raman spectroscopy D. von Stetten, M. Günther, P. Scheerer, D. H. Murgida, M. A. Mroginski, N. Krauss, T. Lamparter, J. Zhang, D. M. Anstrom, R. D. Vierstra, K. T. Forest, P. Hildebrandt Angewandte Chemie International Edition 2008, 47, 4753 - 4755, 10.1002/anie.200705716

59 Electrochemical Growth of Silver Nanocoral Reefs on Electrodes for Protein-Based Bioelectronic Devices J. Feng, P. Hildebrandt, D. H. Murgida Langmuir 2008, 24, 1583 - 1586, 10.1021/la703092c

57 Direct observation of the gating step in protein electron transfer: Electric field controlled protein dynamics A. Kranich, K. H. Ly, P. Hildebrandt, D. H. Murgida Journal of the American Chemical Society 2008, 130, 9844 - 9848, 10.1021/ja8016895

56 Redox-linked protein dynamics probed by time-resolved Surface enhanced infrared absorption spectroscopy N. Wisitruangsakul, I. Zebger, K. H. Ly, D. H. Murgida, P. Hildebrandt Physical Chemistry Chemical Physics 2008, 10, 5276 - 5286, 10.1039/b806528d

55 Raman excitation profiles of ß-carotene - novel insights into the nature of the nu(1)band N. Tschirner, M. Schenderlein, K. Brose, E. Schlodder, M. A. Mroginski, P. Hildebrandt, C. Thomsen Physica Status Solidi B-Basic Solid State Physics 2008, 245, 2225 - 2228, 10.1002/pssb.200879649

54 Gated electron transfer of yeast iso-1 cytochrome c on SAM-coated electrodes J. Feng, D. H. Murgida, T. Utesch, M. A. Mroginski, P. Hildebrandt, I. M. Weidinger Journal of Physical Chemistry B 2008, 112, 15202 - 15211, 10.1021/jp8062383

53 SERR spectroelectrochemical study of a cbb3 oxygen reductase in a biomimetic construct S. Todorovic, A. Verissimo, N. Wisitruangsakul, I. Zebger, P. Hildebrandt, M. M. Pereira, M. S. Teixeira, D. H. Murgida Journal of Physical Chemistry B 2008, 112, 16952 - 16959, 10.1021/jp807862m

52 Spectroscopic insight into the oxygen-tolerant membrane-associated [NiFe]-hydrogenase of Ralstonia eutropha H16 M. Saggu, I. Zebger, M. Ludwig, O. Lenz, B. Friedrich, P. Hildebrandt, F. Lendzian Journal of Biological Chemistry 2009, 284, 16264 - 16276, 10.1074/jbc.M805690200

49 Untersuchung des Katalyseprozesses der membrangebundenen Hydrogenase aus Rastolnia EutrophaH16 mittels oberflächenverstärkter Infrarotabsorptionsspektroskopie N. Wisitruangsakul, O. Lenz, M. Ludwig, B. Friedrich, P. Hildebrandt, F. Lendzian, I. Zebger Angewandte Chemie 2009, 121, 621 - 623, 10.1002/ange.200802633

48 Monitoring catalysis of the membrane-bound hydrogenase of Rastolnia Eutropha by surface enhanced infrared absorption spectroscopy N. Wisitruangsakul, O. Lenz, M. Ludwig, B. Friedrich, P. Hildebrandt, F. Lendzian, I. Zebger Angewandte Chemie International Edition 2009, 48, 611 - 613, 10.1002/anie.200802633

46 Electron transfer dynamics of cytochrome c immobilised on coated silver and silver-gold hybrid elecdtrodes studied by SERR spectroscopy I. M. Weidinger, J. Feng, M. Sezer, U. Kuhlmann, D. H. Murgida, P. Hildebrandt Proceedings of the XXIst International Concerence on Raman Spectroscopy Rob Withnall, Babur Z. Chowdhry IM Publications, Charlton, Chichester 2008, 0, 358 - 359,

45 Elucidation of the chromophore structure in phytochrome - a combined resonance Raman spectroscopic and theoretical approach D. von Stetten, M. Günther, S. Kaminski, P. Scheerer, N. Krauss, T. Lamparter, K. T. Forest, R. D. Vierstra, W. Gärtner, D. H. Murgida, M. A. Mroginski, P. Hildebrandt Proceedings of the XXIst International Conference on Raman Spectroscopy Rob Withnall, Babur Z. Chowdhry IM Publications, Charlton, Chichester 2008, 0, 127 - 129,

44 Supramolecular templates toward nanoflake-metal surfaces Y. Shen, J. Wang, U. Kuhlmann, P. Hildebrandt, K. Ariga, H. Möhwald, D. G. Kurth, T. Nakanishi Chemistry - A European Journal 2009, 15, 2763 - 2767, 10.1002/chem.200802358

43 Resonance Raman study of the superoxide reductase from Archaeoglobus fulgidus, E12 mutants and a 'natural variant' S. Todorovic, J. Rodrigues, A. F. Pinto, C. Romao, C. Thomsen, P. Hildebrandt, M. S. Teixeira, D. H. Murgida Physical Chemistry Chemical Physics 2009, 11, 1809 - 1815, 10.1039/B815489A

41 The electrochemical response of cytochrome c immobilised on smooth and roughened Ag and Au surfaces chemically modified with 11-mercaptounodecanoic acid D. Millo, A. Ranieri, P. Gross, M. Borsari, K. H. Ly, P. Hildebrandt, G. J. L. Wuite, C. Gooijer, G. van der Zwan Journal of Physical Chemistry C 2009, 113, 2861 - 2866, 10.1021/jp807855y

40 Computer simulation and SERR detection of cytochrome c dynamics at SAM-coated electrodes D. A. Paggi, D. F. Martin, A. Kranich, P. Hildebrandt, M. Martí, D. H. Murgida Electrochimica Acta 2009, 54, 4963 - 4970, 10.1016/j.electacta.2009.02.050

39 Chromophore structure of cyanobacterial phytochrome Cph1 in the Pr state: reconciling structural and spectroscopic data by QM/MM calculations M. A. Mroginski, D. von Stetten, F. Velazquez Escobar, H. M. Strauss, S. Kaminski, P. Scheerer, M. Günther, D. H. Murgida, P. Schmieder, C. Bongards, W. Gärtner, J. Maillet, J. Hughes, L. O. Essen, P. Hildebrandt Biophysical Journal 2009, 96, 4153 - 4163, 10.1016/j.bpj.2009.02.029

38 Gated Electron Transfer of Cytochrome c6 at Biomimetic Interfaces: A Time-Resolved SERR Study A. Kranich, H. Naumann, F. P. Molina-Heredia, H. J. Moore, T. R. Lee, S. Lecomte, M. A. De la Rosa, P. Hildebrandt, D. H. Murgida Physical Chemistry Chemical Physics 2009, 11, 7390 - 7397, 10.1039/B904434E

37 Interfacial redox processes of cytochrome b562 P. Zuo, T. Albrecht, P. D. Barker, D. H. Murgida, P. Hildebrandt Physical Chemistry Chemical Physics 2009, 11, 7430 - 7436, 10.1039/B904926F

36 Disentangling interfacial redox processes of proteins by SERR spectroscopy D. H. Murgida, P. Hildebrandt Chemical Society Reviews 2008, 37, 937 - 945, 10.1039/B705976K

13 The mechanism of assembly and cofactor insertion into Rhodobacter capsulatus xanthine dehydrogenase S. Schumann, M. Saggu, N. Moeller, S. D. Anker, F. Lendzian, P. Hildebrandt, S. Leimkühler The Journal Of Biological Chemistry 2008, 283, 16602 - 16611, 10.1074/jbc.M709894200

12 A periplasmic aldehyde oxidoreductase represents the first molybdopterin cytosine dinucleotide cofactor containing molybdo-flavoenzyme from Escherichia coli M. Neumann, G. Mittelstaedt, C. Iobbi-Nivol, M. Saggu, F. Lendzian, P. Hildebrandt, S. Leimkühler FEBS Journal 2009, 276, 2762 - 2774, 10.1111/j.1742-4658.2009.07000.x

11 Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1 S. Schumann, M. Terao, E. Garattini, M. Saggu, F. Lendzian, P. Hildebrandt, S. Leimkühler PLoS ONE 2009, 4, 5348 - 5348, 10.1371/journal.pone.0005348

5 Novel Au-Ag Hybrid Device for Electrochemical SE(R)R Spectroscopy in a Wide Potential and Spectral Range J. Feng, U. Gernert, M. Sezer, U. Kuhlmann, D. H. Murgida, C. David, M. Richter, A. Knorr, P. Hildebrandt, I. M. Weidinger Nano Letters 2009, 9, 298 - 303, 10.1021/nl802934u

Patents

Prof. Dr. Peter Hildebrandt

Photo of Peter  Hildebrandt

Peter Hildebrandt
Technische Universität Berlin
Inst. f. Chemie / FG Biophysikalische Chemie
Straße des 17. Juni 135
10623 Berlin

+49 30 314-21419
Hildebrandt(at)chem.TU-Berlin.DE

 

 

More information

Curriculum vitae
Publications
Further projects