Prof. Dr. Roderich Süssmuth
Research interests
Combinatorial biosynthesis, synthetic biology, biological chemistry of natural products, biocatalysis, enzymatics, antibiotics, structure elucidation,
Research Fields in UniCat
Research Field D4
Research Field E4
Selection of research projects
Structure elucidation
Salmochelins: iron-siderophores and posttranslational modifications
Novel antiinfectives: abyssomicins biosynthesis and mode of action
Inhibitor of cysteine proteases
Nonribosomal peptide synthetases
Feglymycin: a peptide antibiotic with antiviral activity against HIV-1
Proximicin-Netropsin hybrids
UniCat publications
| 749 Biosynthetic gene cluster of the non-ribosomally synthesized cyclodepsipeptide skyllamycin: Deciphering unprecedented ways of unusual hydroxylation reactions S. Pohle, C. Appelt, M. Roux, H. P. Fiedler, R. D. Süssmuth Journal of the American Chemical Society 2011, 133, 6194 - 6205, 10.1021/ja108971p |
| 748 Plantazolicin A and B: Structure elucidation of ribosomally synthesized thiazole/oxazole peptides from Bacillus amyloliquefaciens FZB42 B. Kalyon, S. Helaly, R. Scholz, J. Nachtigall, J. Vater, R. Borriss, R. D. Süssmuth Organic Letters 2011, 13, 2996 - 2999, 10.1021/ol200809m |
| 747 Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan bio-synthesis pathway S. Rausch, A. Hänchen, A. Denisiuk, M. Löhken, T. Schneider, R. D. Süssmuth ChemBioChem 2011, 12, 1171 - 1173, 10.1002/cbic.201100120 |
| 746 Abyssomicin biosynthesis: Formation of an unusual polyketide antibiotic - feeding studies and genetic analysis E. M. Gottardi, J. M. Krawczyk, H. von Suchodoletz, S. Schadt, A. Mühlenweg, G. C. Uguru, S. Pelzer, H. P. Fiedler, M. J. Bibb, J. E. M. Stach, R. D. Süssmuth ChemBioChem 2011, 12, 1401 - 1410, 10.1002/cbic.201100172 |
| 745 Atacamycins A-C, 22-membered antitumor macrolactones produces by Streptomyces sp. C38 J. Nachtigall, A. Kulik, S. Helaly, A. T. Bull, M. Goodfellow, J. A. Asenjo, A. Maier, J. Wiese, J. F. Imhoff, R. D. Süssmuth, H. P. Fiedler The Journal of Antibiotics 2011, 0, 0 - 0, 10.1038/ja.2011.96 |
| 744 Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC W. M. Müller, P. Ensle, B. Krawczyk, R. D. Süssmuth Biochemistry 2011, 50, 8362 - 8373, 10.1021/bi200526q |
| 743 Lichenicidin biosynthesis in Escherichia coli: licFGEHI immunity genes are not essential for lantibiotic production or self-protection T. Caetano, J. M. Krawczyk, E. Mösker, S. Mendo, R. D. Süssmuth Applied and Environmental Microbiology 2011, 0, 5023 - 5026, 10.1128/AEM.00270-11 |
| 531 Fungal cyclooligomer depsipeptides: From classical biochemistry to combinatorial biosynthesis J. Müller, H. von Döhren, I. Molnar, R. D. Süssmuth Natural Product Reports 2011, 28, 99 - 124, 10.1039/C001463J |
| 487 Aromatic C-methyltransferases with antipodal stereoselectivity for structurally diverse phenolic amino acids catalyze the methylation step in the biosynthesis of the actinomycin chromophor I. Crnovcic, R. D. Süssmuth, U. Keller Biochemistry 2010, 49, 9698 - 9705, 10.1021/bi101422r |
| 486 Heterologous expression, biosynthesis and mutagenesis of type II lantibiotics from bacillus licheniformis in escherichia coli T. Caetano, J. M. Krawczyk, E. Mösker, R. D. Süssmuth, S. Mendo Chemistry & Biology 2011, 18, 90 - 100, 10.1016/j.chembiol.2010.11.010 |
| 485 Elaiomycins B and C: Alkylhydrazide Antibiotics from Streptomyces sp. BK 190 S. E. Helaly, A. Pesic , H. P. Fiedler, R. D. Süssmuth Organic Letters 2011, 13, 1052 - 1055, 10.1021/ol1031014 |
| 484 Thioamides in Nature: In Search of Secondary Metabolites in Anaerobic Microorganisms S. Banala, R. D. Süssmuth ChemBioChem 2010, 11, 1335 - 1337, 10.1002/cbic.201000266 |
| 389 In Vitro Synthesis of New Enniatins: Probing the alpha-D-Hydroxy Carboxylic Acid Binding Pocket of the Multienzyme Enniatin Synthetase S. C. Feifel, T. Schmiederer, T. Hornbogen, H. Berg, R. Zocher, R. D. Süssmuth ChemBioChem 2007, 8, 1767 - 1770, 10.1002/cbic.200700377 |
| 316 In vitro Biosynthesis of the Propeptide of Type-II Lantibiotic Labyrinthopeptin A2 Forming a C-C-Bond as a Novel Post-Translational Modification W. M. Müller, T. Schmiederer, P. Ensle, R. D. Süssmuth Angewandte Chemie International Edition 2010, 49, 2436 - 2440, 10.1002/anie.200905909 |
| 314 Total Synthesis of new lipocarbazoles isolated from the Actinomycete Tsukamurella pseudospumae Acta 1857 A. Hänchen, R. D. Süssmuth Synlett 2009, 15, 2483 - 2486, 10.1055/s-0029-1217815 |
| 312 Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity F. E. Wolter, L. Molinari, E. R. Socher, K. Schneider, G. Nicholson, W. Beil, O. Seitz, R. D. Süssmuth Bioorganic & Medicinal Chemistry Letters 2009, 19, 3811 - 3815, 10.1016/j.bmcl.2009.04.042 |
| 8 Module Extension of a Non-Ribosomal Peptide Synthetase of the Glycopeptide Antibiotic Balhimycin Produced by Amycolatopsis balhimycina D. Butz, T. Schmiederer, B. Hadatsch, W. Wohlleben, T. Weber, R. D. Süssmuth Chemistry - A European Journal 2008, 9, 1195 - 1200, 10.1002/cbic.200800068 |
| 7 In vitro Synthesis of New Cyclodepsipeptides of the PF1022-Type: Probing the alpha-D-Hydroxy Acid Tolerance of PF1022 Synthetase J. Müller, S. C. Feifel, T. Schmiederer, R. Zocher, R. D. Süssmuth Chemistry - A European Journal 2009, 10, 323 - 328, 10.1002/cbic.200800539 |
| 6 2-Amino-2-deoxyisochorismate Is a Key Intermediate in Bacillus subtilis p-Aminobenzoic Acid Biosynthesis H. S. Schadt, S. Schadt, F. Oldach, R. D. Süssmuth Journal of the American Chemical Society 2009, 131, 3481 - 3483, 10.1021/ja809283u |
Patents
Highly bridged peptides from Actinomadura namibiensis, Broenstrup, M., Guehring, H., Hoffmann, H., Wink, J., Schmiederer, T., Süssmuth, R., filed on 3/18/2009, published on 10/8/2009 PCT/EP2009/001982
WO2009121483.
Highly bridged peptides from Actinomadura namibiensis, Broenstrup, M., Guehring, H., Hoffmann, H., Wink, J., Schmiederer, T., Süssmuth, R., filed on 4/2/2008, published on 1/12/2011
EP2271665.
