Prof. Dr. Holger Dobbek

Member of UniCat's Executive Board since November 2010

Research interests

Enzymology of reductive CO/CO2 metabolism in bacteria, oxidation state dependent host-guest recognition in biology, molybdoenzymes, iron-sulfur cluster, flavoenzymes, X-ray crystallography

Research Fields in UniCat

Research Field D2
Research Field E2*
Research Field E3
Research Field E4

* Main Research Field

2009-2011: B2

Selection of research projects

  • Stabilization and characterization of various adducts bound to enzymes containing O2-sensitive iron-sulfur cluster
  • Analysing the function of flavoenzymes by combining single-turnover kinetics and X-ray crystallography
  • Structural analysis of an O2-sensitive Mo-Se containing enzyme

Relevant News

Montag, 13. November 2017

A super adhesive made from intestinal bacteria

Manufacturing mussel-based underwater adhesives for healing bone fractures with the help of reprogramed intestinal bacteria / spin-off planned

Donnerstag, 10. August 2017

Photosystem II without Mn4CaO5-Cluster

New research highlight: Holger Dau, Holger Dobbek, Athina Zouni, and coworkers reveal structural insights into the light-driven auto-assembly process of the water-oxidizing Mn4CaO5-cluster in photosystem II.

Mittwoch, 19. Juli 2017

Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase

New research highlight: Peter Hildebrandt, Holger Dobbek, Ingo Zebger, and coworkers investigate the Michaelis complex of the flavoenzyme xenobiotic reductase A with the reactive reduced cofactor bound to its substrates by X-ray crystallography and resonan

Dienstag, 23. Mai 2017

Carbon Monoxide Dehydrogenase Reduces Cyanate to Cyanide

The biocatalytic function of carbon monoxide dehydrogenase (CODH) has a high environmental relevance owing to its ability to reduce CO2. Despite numerous studies on CODH over the past decades, its catalytic mechanism is not yet fully understood. In the pre

Montag, 21. November 2016

Reserach Highlight "Structure of photosystem II and substrate binding at room temperature"

Here we report the use of femtosecond pulses from an X-ray free electron laser (XFEL) to obtain damage-free, room temperature structures of dark-adapted (S1), two-flash illuminated (2F; S3-enriched), and ammonia-bound two-flash illuminated (2F-NH3; S3-enri

Montag, 18. Mai 2015

A blue-print for the activation of Carbon Dioxide

The activation and conversion of carbon dioxide into added-value products is of economical and ecological importance. mehr

Montag, 18. August 2014

How to energize an electron

When an organic chemist needs strong reducing power he can turn to elemental alkali metals in an aprotic medium. When a physiological process requires an “energized” electron, it has to realize it without elemental metals as electron source and within an amehr

Freitag, 07. März 2014

Iron-Sulfur Enzymes - Mechanisms and Applications in Energy, Environment and Medicine

UniCat scientists Silke Leimkühler, Holger Dobbek, and Oliver Lenz have been invited to the Gordon Research Conference on Iron-Sulfur Enzymesmehr

Donnerstag, 18. Juli 2013

Visualizing dioxgen activation

New publication of Holger Dobbek and coworkers in PNASmehr

Freitag, 04. Dezember 2009

News and impressions from General Assembly meeting

Yesterday, Prof. Matthias Driess opened the meeting of the General Assembly and welcomed guests and members of UniCat. Two new members of UniCat presented their research work. Prof. Arne Thomas (TU Berlin) gave a talk on "Functional Porous Materialmehr

Prof. Dr. Holger Dobbek

Holger Dobbek
Humboldt Universität zu Berlin
Institut für Biologie Strukturbiologie/Biochemie
Invalidenstraße 43
Berlin , 10115
+49 30 2093-6369