Prof. Dr. Thomas Friedrich - Publications

2441 Discriminating changes in intracellular NADH/NAD+ levels due to anoxicity and H2 supply in R. eutropha cells using the Frex fluorescence sensor S. Wilkening, F. J. Schmitt, O. Lenz, I. Zebger, M. Horch, T. Friedrich Biochimica et Biophysica Acta (BBA) - Bioenergetics 2019, 1860, 148062– 10.1016/j.bbabio.2019.148062

2325 Photosynthesis supported by a chlorophyll f-dependent, entropy-driven uphill energy transfer in Halomicronema hongdechloris cells adapted to far-red light F. J. Schmitt, Z. Y. Campbell, M. V. Bui, A. Hüls, T. Tomo, M. Chen, E. G. Maksimov, S. I. Allakhverdiev, T. Friedrich Photosynthesis Research 2018, 10.1007/s11120-018-0556-2

2322 Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence T. Baumann, F. J. Schmitt, A. Pelzer, V. J. Spiering, G. J. Freiherr von Sass, T. Friedrich, N. Budisa Journal of Visualized Experiments 2018, 10.3791/57017

2320 Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids J. H. Nickling, T. Baumann, F. J. Schmitt, M. Bartholomae, O. P. Kuipers, T. Friedrich, N. Budisa Journal of Visualized Experiments 2018, 10.3791/57551

2201 Dual-wavelength 3D photoacoustic imaging of mammalian cells using a photoswitchable phytochrome reporter protein J. Märk, H. Dortay, A. Wagener, E. Zhang, J. Buchmann, C. Grötzinger, T. Friedrich, J. Laufer Communications Physics 2018, 1, 10.1038/s42005-017-0003-2

2196 The photocycle of orange carotenoid protein conceals distinct intermediates and asynchronous changes in the carotenoid and protein components E. G. Maksimov, N. N. Sluchanko, Y. B. Slonimskiy, E. A. Slutskaya, A. V. Stepanov, A. M. Argentova-Stevens, E. A. Shirshin, G. V. Tsoraev, K. E. Klementiev, O. V. Slatinskaya, E. P. Lukashev, T. Friedrich, V. Z. Paschenko, A. B. Rubin Scientific Reports 2017, 7, 10.1038/s41598-017-15520-4

2195 Characterization of Frex as an NADH sensor for in vivo applications in the presence of NAD+ and at various pH values S. Wilkening, F. J. Schmitt, M. Horch, I. Zebger, O. Lenz, T. Friedrich Photosynthesis Research 2017, 133, 305–315, 10.1007/s11120-017-0348-0

2194 Biophysical modeling of in vitro and in vivo processes underlying regulated photoprotective mechanism in cyanobacteria E. A. Shirshin, E. E. Nikonova, F. I. Kuzminov, N. N. Sluchanko, I. V. Elanskaya, M. Y. Gorbunov, V. V. Fadeev, T. Friedrich, E. G. Maksimov Photosynthesis Research 2017, 133, 261–271, 10.1007/s11120-017-0377-8

2193 Deletion of the short N-terminal extension in OCP reveals the main site for FRP binding N. N. Sluchanko, Y. B. Slonimskiy, M. Moldenhauer, T. Friedrich, E. G. Maksimov FEBS Letters 2017, 591, 1667–1676, 10.1002/1873-3468.12680

2192 Assembly of photoactive orange carotenoid protein from its domains unravels a carotenoid shuttle mechanism M. Moldenhauer, N. N. Sluchanko, D. Buhrke, D. V. Zlenko, N. N. Tavraz, F. J. Schmitt, P. Hildebrandt, E. G. Maksimov, T. Friedrich Photosynthesis Research 2017, 133, 327–341, 10.1007/s11120-017-0353-3

2191 Interaction of the signaling state analog and the apoprotein form of the orange carotenoid protein with the fluorescence recovery protein M. Moldenhauer, N. N. Sluchanko, N. N. Tavraz, C. Junghans, D. Buhrke, M. Willoweit, L. Chiappisi, F. J. Schmitt, V. Vukojević, E. A. Shirshin, V. Y. Ponomarev, V. Z. Paschenko, M. Gradzielski, E. G. Maksimov, T. Friedrich Photosynthesis Research 2017, 135, 125–139, 10.1007/s11120-017-0346-2

2190 Retinoschisin is linked to retinal Na/K-ATPase signaling and localization K. Plössl, M. Royer, S. Bernklau, N. N. Tavraz, T. Friedrich, J. Wild, B. H. F. Weber, U. Friedrich Molecular Biology of the Cell 2017, 28, 2178–2189, 10.1091/mbc.e17-01-0064

2189 Fluorescent Labeling Preserving OCP Photoactivity Reveals Its Reorganization during the Photocycle E. G. Maksimov, N. N. Sluchanko, K. S. Mironov, E. A. Shirshin, K. E. Klementiev, G. V. Tsoraev, M. Moldenhauer, T. Friedrich, D. A. Los, S. I. Allakhverdiev, V. Z. Paschenko, A. B. Rubin Biophysical Journal 2017, 112, 46–56, 10.1016/j.bpj.2016.11.3193

2188 The Unique Protein-to-Protein Carotenoid Transfer Mechanism E. G. Maksimov, N. N. Sluchanko, Y. B. Slonimskiy, K. S. Mironov, K. E. Klementiev, M. Moldenhauer, T. Friedrich, D. A. Los, V. Z. Paschenko, A. B. Rubin Biophysical Journal 2017, 113, 402–414, 10.1016/j.bpj.2017.06.002

2187 Disruption of Ankyrin B and Caveolin-1 Interaction Sites Alters Na + ,K + -ATPase Membrane Diffusion C. Junghans, V. Vukojević, N. N. Tavraz, E. G. Maksimov, W. Zuschratter, F. J. Schmitt, T. Friedrich Biophysical Journal 2017, 113, 2249–2260, 10.1016/j.bpj.2017.08.053

1995 The purple Trp288Ala mutant of Synechocystis OCP persistently quenches phycobilisome fluorescence and tightly interacts with FRP N. N. Sluchanko, K. E. Klementiev, E. A. Shirshin, G. V. Tsoraev, T. Friedrich, E. G. Maksimov Biochimica et Biophysica Acta Biochimica et Biophysica Acta (BBA) - Bioenergetics 2017, 1858, 1–11, 10.1016/j.bbabio.2016.10.005

1994 The Inner Workings of Proton Slippage through the Sodium Pump T. Friedrich Biophysical Journal 2016, 111, 2342–2344, 10.1016/j.bpj.2016.10.026

1993 Investigation of the NADH/NAD+ ratio in Ralstonia eutropha using the fluorescence reporter protein Peredox V. Tejwani, F. J. Schmitt, S. Wilkening, I. Zebger, M. Horch, O. Lenz, T. Friedrich Biochimica et Biophysica Acta Biochimica et Biophysica Acta (BBA) - Bioenergetics 2017, 1858, 86–94, 10.1016/j.bbabio.2016.11.001

1992 ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of Disease T. Friedrich, N. N. Tavraz, C. Junghans Frontiers in Physiology 2016, 7, 10.3389/fphys.2016.00239

1991 The role of local and remote amino acid substitutions for optimizing fluorescence in bacteriophytochromes: A case study on iRFP D. Buhrke, F. Velazquez Escobar, L. Sauthof, S. Wilkening, N. Herder, N. N. Tavraz, M. Willoweit, A. Keidel, T. Utesch, M. A. Mroginski, F. J. Schmitt, P. Hildebrandt, T. Friedrich Scientific Reports 2016, 6, 28444– 10.1038/srep28444

1660 Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research K. Hobiger, T. Friedrich Frontiers in Pharmacology 2015, 6, 10.3389/fphar.2015.00020

1659 Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin N. D. Eljack, H. Y. M. Ma, J. Drucker, C. Shen, T. W. Hambley, E. J. New, T. Friedrich, R. J. Clarke Metallomics 2014, 6, 2126–2133, 10.1039/C4MT00238E

1658 A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine S. K. Oh, J. I. Baek, K. M. Weigand, H. Venselaar, H. G. P. Swarts, S. H. Park, M. Hashim Raza, D. J. Jung, S. Y. Choi, S. H. Lee, T. Friedrich, G. Vriend, J. B. Koenderink, U. K. Kim, K. Y. Lee European Journal of Human Genetics 2014, 23, 639–645, 10.1038/ejhg.2014.154

1657 A Single-Photon Avalanche Camera for Fluorescence Lifetime Imaging Microscopy and Correlation Spectroscopy M. Vitali, D. Bronzi, A. J. Krmpot, S. N. Nikolic, F. J. Schmitt, C. Junghans, S. Tisa, T. Friedrich, V. Vukojevic, L. Terenius, F. Zappa, R. Rigler IEEE Journal of Selected Topics in Quantum Electronics 2014, 20, 344–353, 10.1109/JSTQE.2014.2333238

1656 Functional analysis of human Na(+)/K(+)-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes S. Spiller, T. Friedrich World Journal of Biological Chemistry 2014, 5, 240–253, 10.4331/wjbc.v5.i2.240

1655 eGFP-pHsens as a highly sensitive fluorophore for cellular pH determination by fluorescence lifetime imaging microscopy (FLIM) F. J. Schmitt, B. Thaa, C. Junghans, M. Vitali, M. Veit, T. Friedrich Biochimica et Biophysica Acta (BBA) - Bioenergetics 2014, 1837, 1581–1593, 10.1016/j.bbabio.2014.04.003

1654 The time course of non-photochemical quenching in phycobilisomes of Synechocystis sp. PCC6803 as revealed by picosecond time-resolved fluorimetry E. G. Maksimov, F. J. Schmitt, E. A. Shirshin, M. D. Svirin, I. V. Elanskaya, T. Friedrich, V. V. Fadeev, V. Z. Paschenko, A. B. Rubin Biochimica et Biophysica Acta (BBA) - Bioenergetics 2014, 1837, 1540–1547, 10.1016/j.bbabio.2014.01.010

1316 Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays K. L. Dürr, N. N. Tavraz, S. Spiller, T. Friedrich Journal of Visualized Experiments 2013, 10.3791/50201

1315 The Linker Pivot in Ci-VSP: The Key to Unlock Catalysis K. Hobiger, T. Utesch, M. A. Mroginski, G. Seebohm, T. Friedrich, S. Barnes PLoS ONE 2013, 8, 10.1371/journal.pone.0070272

1313 Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy T. Pisano, S. Spiller, D. Mei, R. Guerrini, C. Cianchetti, T. Friedrich, D. Pruna Cephalalgia 2013, 33, 1302–1310, 10.1177/0333102413495116

853 Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site K. Abe, K. Tania, T. Friedrich, Y. Fujiyoshia Proceedings of the National Academy of Sciences of the United States of America 2012, 109, 18401–18406, 10.1073/pnas.1212294109

805 Coupling of Ci-VSP Modules Requires a Combination of Structure and Electrostatics within the Linker K. Hobiger, T. Utesch, M. A. Mroginski, T. Friedrich Biophysical Journal 2012, 102, 1313–1322, 10.1016/j.bpj.2012.02.027

803 Control of Gastric H,K-ATPase Activity by Cations, Voltage and Intracellular pH Analyzed by Voltage Clamp Fluorometry in Xenopus Oocytes K. L. Dürr, N. N. Tavraz, T. Friedrich PLoS ONE 2012, 7, 10.1371/journal.pone.0033645

433 Deceleration of the E1P-E2P Transition and Ion Transport by Mutation of Potentially Salt Bridge-forming Residues Lys-791 and Glu-820 in Gastric H+/K+-ATPase K. L. Dürr, I. Seuffert, T. Friedrich The Journal Of Biological Chemistry 2010, 285, 39366–39379, 10.1074/jbc.M110.133470

265 Hyperpolarization-activated inward leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na+/K+ - ATPase Alpha subunit S. Meier, N. N. Tavraz, K. L. Dürr, T. Friedrich The Journal of General Physiology 2010, 135, 115–134, 10.1085/jgp.200910301

264 E2P State Stabilization by the N-terminal Tail of the H,K-ATPase K. L. Dürr, K. Abe, N. N. Tavraz, T. Friedrich The Journal Of Biological Chemistry 2009, 284, 20147–20154, 10.1074/jbc.M109.005769

263 Voltage- and pH-Dependent Changes in Vectoriality of Photocurrents Mediated by Wild-type and Mutant Proteorhodopsins upon Expression in Xenopus Oocytes E. Lörinczi, M. K. Verhoefen, J. Wachtveitl, A. C. Woerner, C. Glaubitz, M. Engelhard, E. Bamberg, T. Friedrich Journal of Molecular Biology 2009, 393, 320–341, 10.1016/j.jmb.2009.07.055

81 Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. M. Dichgans, E. Bamberg, J. B. Koenderink, K. L. Dürr, T. Friedrich, N. N. Tavraz The Journal Of Biological Chemistry 2008, 283, 31097–31106, 10.1074/jbc.M802771200

80 Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraine T. Friedrich, E. Bamberg, T. Freilinger, N. N. Tavraz, K. L. Dürr, J. B. Koenderink Channels 2009, 3, 82–87, 10.4161/chan.3.2.8085

34 Functional Significance of E2 State Stabilization by Specific alpha/beta-Subunit Interactions of Na,K- and H,K-ATPase. K. L. Dürr, N. N. Tavraz, R. E. Dempski, E. Bamberg, T. Friedrich The Journal Of Biological Chemistry 2009, 284, 3842–3854, 10.1074/jbc.M808101200