Publications E4

2621 The femtosecond-to-second photochemistry of red-shifted fast-closing anion channelrhodopsin ACR1 Y. Hontani, M. Broser, A. Silapetere, B. S. Krause, P. Hegemann, J. T. M. Kennis Physical Chemistry Chemical Physics 2017, 19, 30402–30409, 10.1039/C7CP06414D

2615 Crystal structure of the red light-activated channelrhodopsin Chrimson K. Oda, J. Vierock, S. Oishi, S. Rodriguez-Rozada, R. Taniguchi, K. Yamashita, J. S. Wiegert, T. Nishizawa, P. Hegemann, O. Nureki Nature Communications 2018, 9, 10.1038/s41467-018-06421-9

2614 Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2 C. Grimm, A. Silapetere, A. Vogt, Y. A. Bernal Sierra, P. Hegemann Scientific Reports 2018, 8, 10.1038/s41598-018-27690-w

2605 The C-Terminal VPRTES Tail of LL-37 Influences the Mode of Attachment to a Lipid Bilayer and Antimicrobial Activity A. de Miguel Catalina, E. Forbrig, J. Kozuch, C. Nehls, L. Paulowski, T. Gutsmann, P. Hildebrandt, M. A. Mroginski Biochemistry 2019, 58, 2447–2462, 10.1021/acs.biochem.8b01297

2603 Chromophore binding to two cysteines increases quantum yield of near-infrared fluorescent proteins D. Buhrke, N. N. Tavraz, D. M. Shcherbakova, L. Sauthof, M. Moldenhauer, F. Vélazquez Escobar, V. V. Verkhusha, P. Hildebrandt, T. Friedrich Scientific Reports 2019, 9, 10.1038/s41598-018-38433-2

2493 Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals N. R. Casewell, D. Petras, D. C. Card, V. Suranse, A. M. Mychajliw, D. Richards, I. Koludarov, L. O. Albulescu, J. Slagboom, B. F. Hempel, N. M. Ngum, R. J. Kennerley, J. L. Brocca, G. Whiteley, R. A. Harrison, F. M. S. Bolton, J. Debono, F. J. Vonk, J. Alföldi, J. Johnson, E. K. Karlsson, K. Lindblad-Toh, I. R. Mellor, R. D. Süssmuth, B. G. Fry, S. Kuruppu, W. C. Hodgson, J. Kool, T. A. Castoe, I. Barnes, K. Sunagar, E. A. B. Undheim, S. T. Turvey Proceedings of the National Academy of Sciences 2019, 116, 25745–25755, 10.1073/pnas.1906117116

2492 Lichenicidin rational site‐directed mutagenesis library: A tool to generate bioengineered lantibiotics J. Barbosa, T. Caetano, E. Mösker, R. Süssmuth, S. Mendo Biotechnology and Bioengineering 2019, 116, 3053–3062, 10.1002/bit.27130

2491 Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey D. Petras, B. F. Hempel, B. Göçmen, M. Karis, G. Whiteley, S. C. Wagstaff, P. Heiss, N. R. Casewell, A. Nalbantsoy, R. D. Süssmuth Journal of Proteomics 2019, 199, 31–50, 10.1016/j.jprot.2019.02.004

2490 Comparison of actinomycin peptide synthetase formation in and I. Crnovčić, M. Lang, I. Ortel, R. D. Süssmuth, U. Keller Journal of Basic Microbiology 2019, 59, 148–157, 10.1002/jobm.201800244

2433 Investigating the Structure and Dynamics of Apo‐Photosystem II R. Han, K. Rempfer, M. Zhang, H. Dobbek, A. Zouni, H. Dau, S. Luber ChemCatChem 2019, 11, 4072–4080, 10.1002/cctc.201900351

2392 Bioinspired Designs, Molecular Premise and Tools for Evaluating the Ecological Importance of Antimicrobial Peptides E. Ongey, S. Pflugmacher, P. Neubauer Pharmaceuticals 2018, 11, 68– 10.3390/ph11030068

2391 Heterologous Biosynthesis, Modifications and Structural Characterization of Ruminococcin-A, a Lanthipeptide From the Gut Bacterium Ruminococcus gnavus E1, in Escherichia coli E. L. Ongey, R. T. Giessmann, M. Fons, J. Rappsilber, L. Adrian, P. Neubauer Frontiers in Microbiology 2018, 9, 10.3389/fmicb.2018.01688

2370 Protein structures guide the design of a much-needed tool for neuroscience P. Scheerer, E. Unger, L. Tian Nature 2018, 561, 312–313, 10.1038/d41586-018-06670-0

2325 Photosynthesis supported by a chlorophyll f-dependent, entropy-driven uphill energy transfer in Halomicronema hongdechloris cells adapted to far-red light F. J. Schmitt, Z. Y. Campbell, M. V. Bui, A. Hüls, T. Tomo, M. Chen, E. G. Maksimov, S. I. Allakhverdiev, T. Friedrich Photosynthesis Research 2018, 139, 185–201, 10.1007/s11120-018-0556-2

2322 Engineering \'Golden\' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence T. Baumann, F. J. Schmitt, A. Pelzer, V. J. Spiering, G. J. Freiherr von Sass, T. Friedrich, N. Budisa Journal of Visualized Experiments 2018, 10.3791/57017

2320 Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids J. H. Nickling, T. Baumann, F. J. Schmitt, M. Bartholomae, O. P. Kuipers, T. Friedrich, N. Budisa Journal of Visualized Experiments 2018, 10.3791/57551

2317 Prerequisites of Isopeptide Bond Formation in Microcystin Biosynthesis S. Meyer, A. Mainz, J. C. Kehr, R. D. Süssmuth, E. Dittmann ChemBioChem 2017, 18, 2376–2379, 10.1002/cbic.201700389

2316 Correction to: Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides S. Boecker, S. Grätz, D. Kerwat, L. Adam, D. Schirmer, L. Richter, T. Schütze, D. Petras, R. D. Süssmuth, V. Meyer Fungal Biology and Biotechnology 2018, 5, 10.1186/s40694-018-0051-8

2291 Reaction dynamics of the chimeric channelrhodopsin C1C2 Y. Hontani, M. Marazzi, K. Stehfest, T. Mathes, I. H. M. van Stokkum, M. Elstner, P. Hegemann, J. T. M. Kennis Scientific Reports Scientific Reports 2017, 7, 10.1038/s41598-017-07363-w

2290 Molecular determinants of proton selectivity and gating in the red-light activated channelrhodopsin Chrimson J. Vierock, C. Grimm, N. Nitzan, P. Hegemann Scientific Reports Scientific Reports 2017, 7, 10.1038/s41598-017-09600-8

2289 The form and function of channelrhodopsin K. Deisseroth, P. Hegemann Science 2017, 357, 10.1126/science.aan5544

2288 The two parallel photocycles of the Chlamydomonas sensory photoreceptor histidine kinase rhodopsin 1 M. Luck, P. Hegemann Journal of Plant Physiology 2017, 217, 77–84, 10.1016/j.jplph.2017.07.008

2287 Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function J. C. D. Kaufmann, B. S. Krause, C. Grimm, E. Ritter, P. Hegemann, F. J. Bartl Journal of Biological Chemistry 2017, 292, 14205–14216, 10.1074/jbc.M117.779629

2286 Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR B. S. Krause, C. Grimm, J. C. D. Kaufmann, F. Schneider, T. P. Sakmar, F. J. Bartl, P. Hegemann Biophysical Journal 2017, 112, 1166–1175, 10.1016/j.bpj.2017.02.001

2280 The arrestin-1 finger loop interacts with two distinct conformations of active rhodopsin M. Elgeti, R. Kazmin, A. S. Rose, M. Szczepek, P. W. Hildebrand, F. J. Bartl, P. Scheerer, K. P. Hofmann Journal of Biological Chemistry 2018, 293, 4403–4410, 10.1074/jbc.M117.817890

2279 Prospects of In vivo Incorporation of Non-canonical Amino Acids for the Chemical Diversification of Antimicrobial Peptides T. Baumann, J. H. Nickling, M. Bartholomae, A. Buivydas, O. P. Kuipers, N. Budisa Frontiers in Microbiology Frontiers in Microbiology 2017, 8, 10.3389/fmicb.2017.00124

2278 Global substitution of hemeproteins with noncanonical amino acids in Escherichia coli with intact cofactor maturation machinery J. S. Völler, T. M. Thi To, H. Biava, B. Koksch, N. Budisa Enzyme and Microbial Technology Enzyme and Microbial Technology 2017, 106, 55–59, 10.1016/j.enzmictec.2017.06.014

2272 Deciphering the Fluorine Code—The Many Hats Fluorine Wears in a Protein Environment A. A. Berger, J. S. Völler, N. Budisa, B. Koksch Accounts of Chemical Research 2017, 50, 2093–2103, 10.1021/acs.accounts.7b00226

2271 Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology F. Agostini, J. Völler, B. Koksch, C. G. Acevedo‐Rocha, V. Kubyshkin, N. Budisa Angewandte Chemie International Edition 2017, 56, 9680–9703, 10.1002/anie.201610129

2254 Pharmacological and pharmacokinetic properties of lanthipeptides undergoing clinical studies E. L. Ongey, H. Yassi, S. Pflugmacher, P. Neubauer Biotechnology Letters Biotechnology Letters 2017, 39, 473–482, 10.1007/s10529-016-2279-9

2232 Iron Exsolution Phenomena in Lanthanum Strontium Ferrite SOFC Anodes T. Götsch, C. Praty, M. Grünbacher, L. Schlicker, M. F. Bekheet, A. Doran, A. Gurlo, M. Tada, H. Matsui, N. Ishiguro, B. Kloetzer, S. Penner ECS Transactions ECS Transactions 2017, 78, 1327–1341, 10.1149/07801.1327ecst

2231 Surface chemistry and stability of metastable corundum-type In O E. M. Köck, M. Kogler, C. Zhuo, L. Schlicker, M. F. Bekheet, A. Doran, A. Gurlo, S. Penner Physical Chemistry Chemical Physics 2017, 19, 19407–19419, 10.1039/c7cp03632a

2230 Surface chemistry of pure tetragonal ZrO and gas-phase dependence of the tetragonal-to-monoclinic ZrO transformation E. M. Köck, M. Kogler, T. Götsch, L. Schlicker, M. F. Bekheet, A. Doran, A. Gurlo, B. Klötzer, B. Petermüller, D. Schildhammer, N. Yigit, S. Penner Dalton Transactions Dalton Transactions 2017, 46, 4554–4570, 10.1039/c6dt04847a

2201 Dual-wavelength 3D photoacoustic imaging of mammalian cells using a photoswitchable phytochrome reporter protein J. Märk, H. Dortay, A. Wagener, E. Zhang, J. Buchmann, C. Grötzinger, T. Friedrich, J. Laufer Communications Physics Communications Physics 2018, 1, 10.1038/s42005-017-0003-2

2196 The photocycle of orange carotenoid protein conceals distinct intermediates and asynchronous changes in the carotenoid and protein components E. G. Maksimov, N. N. Sluchanko, Y. B. Slonimskiy, E. A. Slutskaya, A. V. Stepanov, A. M. Argentova-Stevens, E. A. Shirshin, G. V. Tsoraev, K. E. Klementiev, O. V. Slatinskaya, E. P. Lukashev, T. Friedrich, V. Z. Paschenko, A. B. Rubin Scientific Reports Scientific Reports 2017, 7, 10.1038/s41598-017-15520-4

2195 Characterization of Frex as an NADH sensor for in vivo applications in the presence of NAD+ and at various pH values S. Wilkening, F. J. Schmitt, M. Horch, I. Zebger, O. Lenz, T. Friedrich Photosynthesis Research Photosynthesis Research 2017, 133, 305–315, 10.1007/s11120-017-0348-0

2194 Biophysical modeling of in vitro and in vivo processes underlying regulated photoprotective mechanism in cyanobacteria E. A. Shirshin, E. E. Nikonova, F. I. Kuzminov, N. N. Sluchanko, I. V. Elanskaya, M. Y. Gorbunov, V. V. Fadeev, T. Friedrich, E. G. Maksimov Photosynthesis Research Photosynthesis Research 2017, 133, 261–271, 10.1007/s11120-017-0377-8

2193 Deletion of the short N-terminal extension in OCP reveals the main site for FRP binding N. N. Sluchanko, Y. B. Slonimskiy, M. Moldenhauer, T. Friedrich, E. G. Maksimov FEBS Letters FEBS Letters 2017, 591, 1667–1676, 10.1002/1873-3468.12680

2192 Assembly of photoactive orange carotenoid protein from its domains unravels a carotenoid shuttle mechanism M. Moldenhauer, N. N. Sluchanko, D. Buhrke, D. V. Zlenko, N. N. Tavraz, F. J. Schmitt, P. Hildebrandt, E. G. Maksimov, T. Friedrich Photosynthesis Research Photosynthesis Research 2017, 133, 327–341, 10.1007/s11120-017-0353-3

2191 Interaction of the signaling state analog and the apoprotein form of the orange carotenoid protein with the fluorescence recovery protein M. Moldenhauer, N. N. Sluchanko, N. N. Tavraz, C. Junghans, D. Buhrke, M. Willoweit, L. Chiappisi, F. J. Schmitt, V. Vukojević, E. A. Shirshin, V. Y. Ponomarev, V. Z. Paschenko, M. Gradzielski, E. G. Maksimov, T. Friedrich Photosynthesis Research 2017, 135, 125–139, 10.1007/s11120-017-0346-2

2190 Retinoschisin is linked to retinal Na/K-ATPase signaling and localization K. Plössl, M. Royer, S. Bernklau, N. N. Tavraz, T. Friedrich, J. Wild, B. H. F. Weber, U. Friedrich Molecular Biology of the Cell Molecular Biology of the Cell 2017, 28, 2178–2189, 10.1091/mbc.e17-01-0064

2189 Fluorescent Labeling Preserving OCP Photoactivity Reveals Its Reorganization during the Photocycle E. G. Maksimov, N. N. Sluchanko, K. S. Mironov, E. A. Shirshin, K. E. Klementiev, G. V. Tsoraev, M. Moldenhauer, T. Friedrich, D. A. Los, S. I. Allakhverdiev, V. Z. Paschenko, A. B. Rubin Biophysical Journal 2017, 112, 46–56, 10.1016/j.bpj.2016.11.3193

2188 The Unique Protein-to-Protein Carotenoid Transfer Mechanism E. G. Maksimov, N. N. Sluchanko, Y. B. Slonimskiy, K. S. Mironov, K. E. Klementiev, M. Moldenhauer, T. Friedrich, D. A. Los, V. Z. Paschenko, A. B. Rubin Biophysical Journal 2017, 113, 402–414, 10.1016/j.bpj.2017.06.002

2187 Disruption of Ankyrin B and Caveolin-1 Interaction Sites Alters Na+,K+-ATPase Membrane Diffusion C. Junghans, V. Vukojević, N. N. Tavraz, E. G. Maksimov, W. Zuschratter, F. J. Schmitt, T. Friedrich Biophysical Journal 2017, 113, 2249–2260, 10.1016/j.bpj.2017.08.053

2169 An expanded genetic code for probing the role of electrostatics in enzyme catalysis by vibrational Stark spectroscopy J. S. Völler, H. Biava, P. Hildebrandt, N. Budisa Biochimica et Biophysica Acta (BBA) - General Subjects Biochimica et Biophysica Acta (BBA) - General Subjects 2017, 1861, 3053–3059, 10.1016/j.bbagen.2017.02.009

2161 Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6 B. M. Qureshi, A. Schmidt, E. Behrmann, J. Bürger, T. Mielke, C. M. T. Spahn, M. Heck, P. Scheerer Nature Communications Nature Communications 2018, 9, 10.1038/s41467-017-02569-y

2130 Structural mechanism of arrestin activation P. Scheerer, M. E. Sommer Current Opinion in Structural Biology Current Opinion in Structural Biology 2017, 45, 160–169, 10.1016/

2129 Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work G. Kleinau, C. L. Worth, A. Kreuchwig, H. Biebermann, P. Marcinkowski, P. Scheerer, G. Krause Frontiers in Endocrinology Frontiers in Endocrinology 2017, 8, 10.3389/fendo.2017.00086

2125 Blue-light reception through quaternary transitions C. Engelhard, R. P. Diensthuber, A. Möglich, R. Bittl Scientific Reports Scientific Reports 2017, 7, 10.1038/s41598-017-01497-7

2122 Highly active promoters and native secretion signals for protein production during extremely low growth rates in Aspergillus niger F. Wanka, M. Arentshorst, T. C. Cairns, T. Jørgensen, A. F. J. Ram, V. Meyer Microbial Cell Factories Microbial Cell Factories 2016, 15, 10.1186/s12934-016-0543-2

2121 Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper V. Meyer, M. R. Andersen, A. A. Brakhage, G. H. Braus, M. X. Caddick, T. C. Cairns, R. P. de Vries, T. Haarmann, K. Hansen, C. Hertz-Fowler, S. Krappmann, U. H. Mortensen, M. A. Peñalva, A. F. J. Ram, R. M. Head Fungal Biology and Biotechnology Fungal Biology and Biotechnology 2016, 3, 10.1186/s40694-016-0024-8

2120 A Transcriptome Meta-Analysis Proposes Novel Biological Roles for the Antifungal Protein AnAFP in Aspergillus niger N. Paege, S. Jung, P. Schäpe, D. Müller-Hagen, J. P. Ouedraogo, C. Heiderich, J. Jedamzick, B. M. Nitsche, C. A. van den Hondel, A. F. Ram, V. Meyer PLOS ONE PLOS ONE 2016, 11, 10.1371/journal.pone.0165755

2107 Divalent Cations Increase DNA Repair Activities of Bacterial (6-4) Photolyases H. Ma, F. Zhang, E. Ignatz, M. Suehnel, P. Xue, P. Scheerer, L. O. Essen, N. Krauß, T. Lamparter Photochemistry and Photobiology Photochemistry and Photobiology 2017, 93, 323–330, 10.1111/php.12698

2105 Crystal Structures of Bacterial (6-4) Photolyase Mutants with Impaired DNA Repair Activity F. Zhang, H. Ma, K. Bowatte, D. Kwiatkowski, E. Mittmann, H. Qasem, N. Krauß, X. Zeng, Z. Ren, P. Scheerer, X. Yang, T. Lamparter Photochemistry and Photobiology Photochemistry and Photobiology 2017, 93, 304–314, 10.1111/php.12699

2100 Using Separable Nonnegative Matrix Factorization Techniques for the Analysis of Time-Resolved Raman Spectra R. Luce, P. Hildebrandt, U. Kuhlmann, J. Liesen Applied Spectroscopy Applied Spectroscopy 2016, 70, 1464–1475, 10.1177/0003702816662600

2094 MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing M. Menger, A. Yarman, J. Erdőssy, H. Yildiz, R. Gyurcsányi, F. Scheller Biosensors Biosensors 2016, 6, 35– 10.3390/bios6030035

2093 MIP-esterase/Tyrosinase Combinations for Paracetamol and Phenacetin A. Yarman, F. W. Scheller Electroanalysis 2016, 28, 2222–2227, 10.1002/elan.201600042

2076 Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation J. S. Völler, M. Dulic, U. I. M. Gerling-Driessen, H. Biava, T. Baumann, N. Budisa, I. Gruic-Sovulj, B. Koksch ACS Central Science ACS Central Science 2016, 3, 73–80, 10.1021/acscentsci.6b00339

2055 Wiring of the aldehyde oxidoreductase PaoABC to electrode surfaces via entrapment in low potential phenothiazine-modified redox polymers P. Pinyou, A. Ruff, S. Pöller, S. Alsaoub, S. Leimkühler, U. Wollenberger, W. Schuhmann Bioelectrochemistry 2016, 109, 24–30, 10.1016/j.bioelechem.2015.12.005

2047 – -Amide isomerism of the 3,4-dehydroproline residue, the ‘unpuckered’ proline V. Kubyshkin, N. Budisa Beilstein Journal of Organic Chemistry 2016, 12, 589–593, 10.3762/bjoc.12.57

2046 Orthogonal Protein Translation Using Pyrrolysyl-tRNA Synthetases for Single- and Multiple-Noncanonical Amino Acid Mutagenesis T. Baumann, M. Exner, N. Budisa Advances in Biochemical Engineering/Biotechnology Springer International Publishing Switzerland Springer Berlin Heidelberg 2016,

2045 Photochemical formation of quinone methides from peptides containing modified tyrosine A. Husak, B. P. Noichl, T. Šumanovac Ramljak, M. Sohora, Đ. Škalamera, N. Budiša, N. Basarić Organic & Biomolecular Chemistry Org. Biomol. Chem. 2016, 14, 10894–10905, 10.1039/C6OB02191C

2044 Energetic contribution to both acidity and conformational stability in peptide models V. Kubyshkin, P. Durkin, N. Budisa New Journal of Chemistry New J. Chem. 2016, 40, 5209–5220, 10.1039/C5NJ03611A

2043 Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins M. Exner, S. Köhling, J. Rivollier, S. Gosling, P. Srivastava, Z. Palyancheva, P. Herdewijn, M. P. Heck, J. Rademann, N. Budisa Molecules Molecules 2016, 21, 287– 10.3390/molecules21030287

2042 Congeneric lipases with improved catalytic activity and substrate accessibility / Engineering lipases with an expanded genetic code. A. De Simone, M. G. Hoesl, N. Budisa Applied Biocatalysis - From Fundamental Science to Industrial Applications Garabed Antranikian Wiley-VCH 2016,

2041 Construction of a polyproline structure with hydrophobic exterior using octahydroindole-2-carboxylic acid V. Kubyshkin, N. Budisa Organic & Biomolecular Chemistry Org. Biomol. Chem. 2017, 15, 619–627, 10.1039/C6OB02306A

2040 One-Pot Synthesis of Unprotected Anomeric Glycosyl Thiols in Water for Glycan Ligation Reactions with Highly Functionalized Sugars S. Köhling, M. P. Exner, S. Nojoumi, J. Schiller, N. Budisa, J. Rademann Angewandte Chemie International Edition 2016, 55, 15510–15514, 10.1002/anie.201607228

2039 Design of -Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant M. P. Exner, T. Kuenzl, T. M. T. To, Z. Ouyang, S. Schwagerus, M. G. Hoesl, C. P. R. Hackenberger, M. C. Lensen, S. Panke, N. Budisa ChemBioChem 2017, 18, 85–90, 10.1002/cbic.201600537

2038 Optogenetic acidification of synaptic vesicles and lysosomes B. R. Rost, F. Schneider, M. K. Grauel, C. Wozny, C. G Bentz, A. Blessing, T. Rosenmund, T. J. Jentsch, D. Schmitz, P. Hegemann, C. Rosenmund Nature Neuroscience 2015, 18, 1845–1852, 10.1038/nn.4161

2037 Optogenetic approaches addressing extracellular modulation of neural excitability E. A. Ferenczi, J. Vierock, K. Atsuta-Tsunoda, S. P. Tsunoda, C. Ramakrishnan, C. Gorini, K. Thompson, S. Y. Lee, A. Berndt, C. Perry, S. Minniberger, A. Vogt, J. Mattis, R. Prakash, S. Delp, K. Deisseroth, P. Hegemann Scientific Reports Scientific Reports 2016, 6, 10.1038/srep23947

2036 Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity A. Berndt, S. Y. Lee, J. Wietek, C. Ramakrishnan, E. E. Steinberg, A. J. Rashid, H. Kim, S. Park, A. Santoro, P. W. Frankland, S. M. Iyer, S. Pak, S. Ährlund-Richter, S. L. Delp, R. C. Malenka, S. A. Josselyn, M. Carlén, P. Hegemann, K. Deisseroth Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences 2016, 113, 822–829, 10.1073/pnas.1523341113

2035 Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy P. E. Konold, T. Mathes, J. Weiβenborn, M. L. Groot, P. Hegemann, J. T. M. Kennis The Journal of Physical Chemistry Letters The Journal of Physical Chemistry Letters 2016, 7, 3472–3476, 10.1021/acs.jpclett.6b01484

2034 Photoadduct Formation from the FMN Singlet Excited State in the LOV2 Domain of Phototropin J. Zhu, T. Mathes, Y. Hontani, M. T. A. Alexandre, K. C. Toh, P. Hegemann, J. T. M. Kennis The Journal of Physical Chemistry Letters The Journal of Physical Chemistry Letters 2016, 7, 4380–4384, 10.1021/acs.jpclett.6b02075

2008 The -Carbamoyl-Transferase Alb15 Is Responsible for the Modification of Albicidin D. Petras, D. Kerwat, A. Pesic, B. F. Hempel, L. von Eckardstein, S. Semsary, J. Arasté, M. Marguerettaz, M. Royer, S. Cociancich, R. D. Süssmuth ACS Chemical Biology ACS Chemical Biology 2016, 11, 1198–1204, 10.1021/acschembio.5b01001

2007 Top-down venomics of the East African green mamba, Dendroaspis angusticeps , and the black mamba, Dendroaspis polylepis , highlight the complexity of their toxin arsenals D. Petras, P. Heiss, R. A. Harrison, R. D. Süssmuth, J. J. Calvete Journal of Proteomics Journal of Proteomics 2016, 146, 148–164, 10.1016/j.jprot.2016.06.018

2006 Leader Peptide‐Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease‐Targeted Libraries E. Reyna‐González, B. Schmid, D. Petras, R. D. Süssmuth, E. Dittmann Angewandte Chemie 2016, 128, 9544–9547, 10.1002/ange.201604345

2005 Towards Biocontained Cell Factories: An Evolutionarily Adapted Escherichia coliStrain Produces a New-to-nature Bioactive Lantibiotic ContainingThienopyrrole-Alanine A. Kuthning, P. Durkin, S. Oehm, M. G. Hoesl, N. Budisa, R. D. Süssmuth Scientific Reports Scientific Reports 2016, 6, 10.1038/srep33447

1962 Lanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical production E. L. Ongey, P. Neubauer Microbial Cell Factories Microbial Cell Factories 2016, 15, 10.1186/s12934-016-0502-y

1919 Leader Peptide‐Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease‐Targeted Libraries E. Reyna‐González, B. Schmid, D. Petras, R. D. Süssmuth, E. Dittmann Angewandte Chemie International Edition 2016, 55, 9398–9401, 10.1002/anie.201604345

1907 Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS S. Meyer, J. C. Kehr, A. Mainz, D. Dehm, D. Petras, R. D. Süssmuth, E. Dittmann Cell Chemical Biology Cell Chemical Biology 2016, 23, 462–471, 10.1016/j.chembiol.2016.03.011

1897 The Cell Factory Aspergillus Enters the Big Data Era: Opportunities and Challenges for Optimising Product Formation. V. Meyer, M. Fiedler, B. Nitsche, R. King Advances in Biochemical Engineering/Biotechnology 2015, 149, 91–132, 10.1007/10_2014_297

1866 A Fluorometric Activity Assay for Light-Regulated Cyclic-Nucleotide-Monophosphate Actuators C. H. Schumacher, H. G. Körschen, C. Nicol, C. Gasser, R. Seifert, M. Schwärzel, A. Möglich Methods in Molecular Biology 2016, 1408, 93–105, 10.1007/978-1-4939-3512-3_7

1865 Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors R. Ohlendorf, C. H. Schumacher, F. Richter, A. Möglich ACS Synthetic Biology ACS Synthetic Biology 2016, 5, 1117–1126, 10.1021/acssynbio.6b00028

1830 Unlocking the potential of fungi: the QuantFung project Z. Büttel, R. Díaz, B. Dirnberger, M. Flak, S. Grijseels, M. J. Kwon, J. C. F. Nielsen, Y. Nygård, P. Phule, C. Pohl, S. Prigent, M. Randelovic, T. Schütze, D. Troppens, A. Viggiano Fungal Biology and Biotechnology Fungal Biology and Biotechnology 2015, 2, 10.1186/s40694-015-0016-0

1829 GTP-binding protein Era: a novel gene target for biofuel production G. P. Voshol, V. Meyer, C. A. M. J. J. van den Hondel BMC Biotechnology BMC Biotechnology 2015, 15, 10.1186/s12896-015-0132-1

1828 Tet-on, or Tet-off, that is the question: Advanced conditional gene expression in Aspergillus F. Wanka, T. Cairns, S. Boecker, C. Berens, A. Happel, X. Zheng, J. Sun, S. Krappmann, V. Meyer Fungal Genetics and Biology Fungal Genetics and Biology 2016, 89, 72–83, 10.1016/j.fgb.2015.11.003

1827 Rational biosynthetic approaches for the production of new-to-nature compounds in fungi S. Boecker, S. Zobel, V. Meyer, R. D. Süssmuth Fungal Genetics and Biology Fungal Genetics and Biology 2016, 89, 89–101, 10.1016/j.fgb.2016.02.003

1826 Immobilization of thermostable nucleoside phosphorylases on MagReSyn® epoxide microspheres and their application for the synthesis of 2,6-dihalogenated purine nucleosides X. Zhou, I. A. Mikhailopulo, M. N. Cruz Bournazou, P. Neubauer Journal of Molecular Catalysis B: Enzymatic 2015, 115, 119–127, 10.1016/j.molcatb.2015.02.009

1825 Molecularly Imprinted Electropolymer for a Hexameric Heme Protein with Direct Electron Transfer and Peroxide Electrocatalysis L. Peng, A. Yarman, K. Jetzschmann, J. H. Jeoung, D. Schad, H. Dobbek, U. Wollenberger, F. Scheller Sensors Sensors 2016, 16, 272– 10.3390/s16030272

1824 Electrosynthesized molecularly imprinted polymers for protein recognition J. Erdőssy, V. Horváth, A. Yarman, F. W. Scheller, R. E. Gyurcsányi TrAC Trends in Analytical Chemistry TrAC Trends in Analytical Chemistry 2016, 79, 179–190, 10.1016/j.trac.2015.12.018

1823 Microelectrospotting as a new method for electrosynthesis of surface-imprinted polymer microarrays for protein recognition M. Bosserdt, J. Erdőssy, G. Lautner, J. Witt, K. Köhler, N. Gajovic-Eichelmann, A. Yarman, G. Wittstock, F. W. Scheller, R. E. Gyurcsányi Biosensors and Bioelectronics 2015, 73, 123–129, 10.1016/j.bios.2015.05.049

1822 Vectorially Imprinted Hybrid Nanofilm for Acetylcholinesterase Recognition K. J. Jetzschmann, G. Jágerszki, D. Dechtrirat, A. Yarman, N. Gajovic-Eichelmann, H. D. Gilsing, B. Schulz, R. E. Gyurcsányi, F. W. Scheller Advanced Functional Materials 2015, 25, 5178–5183, 10.1002/adfm.201501900

1821 Cytochrome c-Derived Hybrid Systems Based on Moleculary Imprinted Polymers A. Yarman, D. Dechtrirat, M. Bosserdt, K. J. Jetzschmann, N. Gajovic-Eichelmann, F. W. Scheller Electroanalysis 2015, 27, 573–586, 10.1002/elan.201400592

1819 Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria E. Dittmann, M. Gugger, K. Sivonen, D. P. Fewer Trends in Microbiology Trends in Microbiology 2015, 23, 642–652, 10.1016/j.tim.2015.07.008

1813 Mass spectrometry guided venom profiling and bioactivity screening of the Anatolian Meadow Viper, Vipera anatolica B. Göçmen, P. Heiss, D. Petras, A. Nalbantsoy, R. D. Süssmuth Toxicon Toxicon 2015, 107, 163–174, 10.1016/j.toxicon.2015.09.013

1812 Streptocollin, a Type IV Lanthipeptide Produced by Tü 365 D. Iftime, M. Jasyk, A. Kulik, J. F. Imhoff, E. Stegmann, W. Wohlleben, R. D. Süssmuth, T. Weber ChemBioChem 2015, 16, 2615–2623, 10.1002/cbic.201500377

1811 The Supersized Class III Lanthipeptide Stackepeptin Displays Motif Multiplication in the Core Peptide N. A. Jungmann, E. F. van Herwerden, M. Hügelland, R. D. Süssmuth ACS Chemical Biology ACS Chemical Biology 2015, 11, 69–76, 10.1021/acschembio.5b00651

1810 Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism M. Gonsior, A. Mühlenweg, M. Tietzmann, S. Rausch, A. Poch, R. D. Süssmuth ChemBioChem 2015, 16, 2610–2614, 10.1002/cbic.201500432

1809 Reprogramming the Biosynthesis of Cyclodepsipeptide Synthetases to Obtain New Enniatins and Beauvericins S. Zobel, S. Boecker, D. Kulke, D. Heimbach, V. Meyer, R. D. Süssmuth ChemBioChem 2016, 17, 283–287, 10.1002/cbic.201500649

1762 Mimicking Tyrosine Phosphorylation in Human Cytochrome  by the Evolved tRNA Synthetase Technique A. Guerra-Castellano, A. Díaz-Quintana, B. Moreno-Beltrán, J. López-Prados, P. M. Nieto, W. Meister, J. Staffa, M. Teixeira, P. Hildebrandt, M. A. De la Rosa, I. Díaz-Moreno Chemistry - A European Journal 2015, 21, 15004–15012, 10.1002/chem.201502019

1750 Toward intrinsically colored peptides: Synthesis and investigation of the spectral properties of methylated azatryptophans in tryptophan-cage mutants B. P. Noichl, P. M. Durkin, N. Budisa Biopolymers Biopolymers 2015, 104, 585–600, 10.1002/bip.22709

1749 Dendronylation: Residue-specific chemoselective attachment of oligoglycerol dendrimers on proteins with noncanonical amino acids Y. Ma, B. N. S. Thota, R. Haag, N. Budisa Bioorganic & Medicinal Chemistry Letters 2015, 25, 5247–5249, 10.1016/j.bmcl.2015.09.055

1748 Chemical Evolution of a Bacterial Proteome M. G. Hoesl, S. Oehm, P. Durkin, E. Darmon, L. Peil, H. R. Aerni, J. Rappsilber, J. Rinehart, D. Leach, D. Söll, N. Budisa Angewandte Chemie International Edition 2015, 54, 10030–10034, 10.1002/anie.201502868

1747 Chemische Evolution eines bakteriellen Proteoms M. G. Hoesl, S. Oehm, P. Durkin, E. Darmon, L. Peil, H. R. Aerni, J. Rappsilber, J. Rinehart, D. Leach, D. Söll, N. Budisa Angewandte Chemie 2015, 127, 10168–10172, 10.1002/ange.201502868

1746 Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome L. K. Doerfel, I. Wohlgemuth, V. Kubyshkin, A. L. Starosta, D. N. Wilson, N. Budisa, M. V. Rodnina Journal of the American Chemical Society 2015, 137, 12997–13006, 10.1021/jacs.5b07427

1732 Signal transduction in light–oxygen–voltage receptors lacking the adduct-forming cysteine residue E. F. Yee, R. P. Diensthuber, A. T. Vaidya, P. P. Borbat, C. Engelhard, J. H. Freed, R. Bittl, A. Möglich, B. R. Crane Nature Communications Nature Communications 2015, 6, 10.1038/ncomms10079

1714 Minimum Information about a Biosynthetic Gene cluster M. H. Medema, R. Kottmann, P. Yilmaz, M. Cummings, J. B. Biggins, K. Blin, I. de Bruijn, Y. H. Chooi, J. Claesen, R. C. Coates, P. Cruz-Morales, S. Duddela, S. Düsterhus, D. J. Edwards, D. P. Fewer, N. Garg, C. Geiger, J. P. Gomez-Escribano, A. Greule, M. Hadjithomas, A. S. Haines, E. J. N. Helfrich, M. L. Hillwig, K. Ishida, A. C. Jones, C. S. Jones, K. Jungmann, C. Kegler, H. U. Kim, P. Kötter, D. Krug, J. Masschelein, A. V. Melnik, S. M. Mantovani, E. A. Monroe, M. Moore, N. Moss, H. W. Nützmann, G. Pan, A. Pati, D. Petras, F. J. Reen, F. Rosconi, Z. Rui, Z. Tian, N. J. Tobias, Y. Tsunematsu, P. Wiemann, E. Wyckoff, X. Yan, G. Yim, F. Yu, Y. Xie, B. Aigle, A. K. Apel, C. J. Balibar, E. P. Balskus, F. Barona-Gómez, A. Bechthold, H. B. Bode, R. Borriss, S. F. Brady, A. A. Brakhage, P. Caffrey, Y. Q. Cheng, J. Clardy, R. J. Cox, R. De Mot, S. Donadio, M. S. Donia, W. A. van der Donk, P. C. Dorrestein, S. Doyle, A. J. M. Driessen, M. Ehling-Schulz, K. D. Entian, M. A. Fischbach, L. Gerwick, W. H. Gerwick, H. Gross, B. Gust, C. Hertweck, M. Höfte, S. E. Jensen, J. Ju, L. Katz, L. Kaysser, J. L. Klassen, N. P. Keller, J. Kormanec, O. P. Kuipers, T. Kuzuyama, N. C. Kyrpides, H. J. Kwon, S. Lautru, R. Lavigne, C. Y. Lee, B. Linquan, X. Liu, W. Liu, A. Luzhetskyy, T. Mahmud, Y. Mast, C. Méndez, M. Metsä-Ketelä, J. Micklefield, D. A. Mitchell, B. S. Moore, L. M. Moreira, R. Müller, B. A. Neilan, M. Nett, J. Nielsen, F. O'Gara, H. Oikawa, A. Osbourn, M. S. Osburne, B. Ostash, S. M. Payne, J. L. Pernodet, M. Petricek, J. Piel, O. Ploux, J. M. Raaijmakers, J. A. Salas, E. K. Schmitt, B. Scott, R. F. Seipke, B. Shen, D. H. Sherman, K. Sivonen, M. J. Smanski, M. Sosio, E. Stegmann, R. D. Süssmuth, K. Tahlan, C. M. Thomas, Y. Tang, A. W. Truman, M. Viaud, J. D. Walton, C. T. Walsh, T. Weber, G. P. van Wezel, B. Wilkinson, J. M. Willey, W. Wohlleben, G. D. Wright, N. Ziemert, C. Zhang, S. B. Zotchev, R. Breitling, E. Takano, F. O. Glöckner Nature Chemical Biology 2015, 11, 625–631, 10.1038/nchembio.1890

1705 Venom Proteomics of Indonesian King Cobra, : Integrating Top-Down and Bottom-Up Approaches D. Petras, P. Heiss, R. D. Süssmuth, J. J. Calvete Journal of Proteome Research Journal of Proteome Research 2015, 14, 2539–2556, 10.1021/acs.jproteome.5b00305

1703 The Albicidin Resistance Factor AlbD Is a Serine Endopeptidase That Hydrolyzes Unusual Oligoaromatic-Type Peptides L. Vieweg, J. Kretz, A. Pesic, D. Kerwat, S. Grätz, M. Royer, S. Cociancich, A. Mainz, R. D. Süssmuth Journal of the American Chemical Society 2015, 137, 7608–7611, 10.1021/jacs.5b04099

1702 Scale-up bioprocess development for production of the antibiotic valinomycin in Escherichia coli based on consistent fed-batch cultivations J. Li, J. Jaitzig, P. Lu, R. D. Süssmuth, P. Neubauer Microbial Cell Factories Microbial Cell Factories 2015, 14, 10.1186/s12934-015-0272-y

1669 Photochemical chromophore isomerization in histidine kinase rhodopsin HKR1 M. Luck, S. Bruun, A. Keidel, P. Hegemann, P. Hildebrandt FEBS Letters FEBS Letters 2015, 589, 1067–1071, 10.1016/j.febslet.2015.03.024

1668 Orthogonal Translation Meets Electron Transfer: In Vivo Labeling of Cytochrome for Probing Local Electric Fields J. Völler, H. Biava, B. Koksch, P. Hildebrandt, N. Budisa ChemBioChem 2015, 16, 742–745, 10.1002/cbic.201500022

1596 Systems Approaches to Predict the Functions of Glycoside Hydrolases during the Life Cycle of Aspergillus niger Using Developmental Mutants ∆brlA and ∆flbA J. M. van Munster, B. M. Nitsche, M. Akeroyd, L. Dijkhuizen, M. J. E. C. van der Maarel, A. F. J. Ram PLOS ONE PLOS ONE 2015, 10, 10.1371/journal.pone.0116269

1595 Molecular genetic analysis of vesicular transport in Aspergillus niger reveals partial conservation of the molecular mechanism of exocytosis in fungi M. J. Kwon, M. Arentshorst, M. Fiedler, F. L. M. de Groen, P. J. Punt, V. Meyer, A. F. J. Ram Microbiology Microbiology 2014, 160, 316–329, 10.1099/mic.0.074252-0

1594 A bifunctional enzyme from Rhodococcus erythropolis exhibiting secondary alcohol dehydrogenase-catalase activities E. Martinez-Rojas, T. Kurt, U. Schmidt, V. Meyer, L. A. Garbe Applied Microbiology and Biotechnology Applied Microbiology and Biotechnology 2014, 98, 9249–9258, 10.1007/s00253-014-5808-2

1593 The capacity of Aspergillus niger to sense and respond to cell wall stress requires at least three transcription factors: RlmA, MsnA and CrzA M. R. Fiedler, A. Lorenz, B. M. Nitsche, C. A. van den Hondel, A. F. Ram, V. Meyer Fungal Biology and Biotechnology Fungal Biology and Biotechnology 2014, 1, 10.1186/s40694-014-0005-8

1592 Transcriptomics of Industrial Filamentous Fungi: A New View on Regulation, Physiology, and Application. B. Nitsche, V. Meyer Fungal Genomics, The Mycota XIII Nouwrosian M Springer 2014,

1587 Applying γ-Substituted Prolines in the Peptide: Polarity Contradicts Preorganization D. Dietz, V. Kubyshkin, N. Budisa ChemBioChem 2015, 16, 403–406, 10.1002/cbic.201402654

1586 Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability N. Nischan, H. D. Herce, F. Natale, N. Bohlke, N. Budisa, M. C. Cardoso, C. P. R. Hackenberger Angewandte Chemie International Edition 2015, 54, 1950–1953, 10.1002/anie.201410006

1582 Coupling Bioorthogonal Chemistries with Artificial Metabolism: Intracellular Biosynthesis of Azidohomoalanine and Its Incorporation into Recombinant Proteins Y. Ma, H. Biava, R. Contestabile, N. Budisa, M. di Salvo Molecules Molecules 2014, 19, 1004–1022, 10.3390/molecules19011004

1581 Sense codon emancipation for proteome-wide incorporation of noncanonical amino acids: rare isoleucine codon AUA as a target for genetic code expansion N. Bohlke, N. Budisa FEMS Microbiology Letters FEMS Microbiology Letters 2014, 351, 133–144, 10.1111/1574-6968.12371

1579 Evolution of fluorinated enzymes: An emerging trend for biocatalyst stabilization H. Biava, N. Budisa Engineering in Life Sciences 2014, 14, 340–351, 10.1002/elsc.201300049

1560 The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo R. Dornetshuber-Fleiss, D. Heilos, T. Mohr, L. Richter, R. D. Süssmuth, M. Zlesak, A. Novicky, P. Heffeter, R. Lemmens-Gruber, W. Berger Biochemical Pharmacology Biochemical Pharmacology 2015, 93, 318–331, 10.1016/j.bcp.2014.12.013

1559 The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine S. Cociancich, A. Pesic, D. Petras, S. Uhlmann, J. Kretz, V. Schubert, L. Vieweg, S. Duplan, M. Marguerettaz, J. Noëll, I. Pieretti, M. Hügelland, S. Kemper, A. Mainz, P. Rott, M. Royer, R. D. Süssmuth Nature Chemical Biology 2015, 11, 195–197, 10.1038/nchembio.1734

1558 Production of the Catechol Type Siderophore Bacillibactin by the Honey Bee Pathogen Paenibacillus larvae G. Hertlein, S. Müller, E. Garcia-Gonzalez, L. Poppinga, R. D. Süssmuth, E. Genersch PLoS ONE 2014, 9, 10.1371/journal.pone.0108272

1552 Site-Directed and Global Incorporation of Orthogonal and Isostructural Noncanonical Amino Acids into the Ribosomal Lasso Peptide Capistruin R. S. Al Toma, A. Kuthning, M. P. Exner, A. Denisiuk, J. Ziegler, N. Budisa, R. D. Süssmuth ChemBioChem 2015, 16, 503–509, 10.1002/cbic.201402558

1551 Bacillus subtilis as heterologous host for the secretory production of the non-ribosomal cyclodepsipeptide enniatin S. Zobel, J. Kumpfmüller, R. D. Süssmuth, T. Schweder Applied Microbiology and Biotechnology Applied Microbiology and Biotechnology 2014, 99, 681–691, 10.1007/s00253-014-6199-0

1550 Engineering of Aspergillus niger for the production of secondary metabolites L. Richter, F. Wanka, S. Boecker, D. Storm, T. Kurt, Ö. Vural, R. Süßmuth, V. Meyer Fungal Biology and Biotechnology Fungal Biology and Biotechnology 2014, 1, 10.1186/s40694-014-0004-9

1549 Dissecting Reactions of Nonlinear Precursor Peptide Processing of the Class III Lanthipeptide Curvopeptin N. A. Jungmann, B. Krawczyk, M. Tietzmann, P. Ensle, R. D. Süssmuth Journal of the American Chemical Society 2014, 136, 15222–15228, 10.1021/ja5062054

1534 Type II thioesterase improves heterologous biosynthesis of valinomycin in Escherichia coli J. Li, J. Jaitzig, L. Theuer, O. E. Legala, R. D. Süssmuth, P. Neubauer Journal of Biotechnology 2015, 193, 16–22, 10.1016/j.jbiotec.2014.10.037

1493 A Prokaryotic (6-4) photolyase with a DMRL chromophore and an iron–sulfur cluster T. Lamparter, F. Zhang, D. Graf, J. Wesslowski, I. Oberpichler, V. Schuenemann, N. Krauß, P. Scheerer Encyclopedia of Inorganic and Bioinorganic Chemistry Robert A. Scott Wiley Online Library 2014, 1–13, 10.1002/9781119951438.eibc2271

1492 Biosynthesis and Function of Extracellular Glycans in Cyanobacteria J. C. Kehr, E. Dittmann Life Life 2015, 5, 164–180, 10.3390/life5010164

1491 Functional assessment of mycosporine-like amino acids in strain PCC 7806 C. Hu, G. Völler, R. Süßmuth, E. Dittmann, J. C. Kehr Environmental Microbiology Environmental Microbiology 2015, 17, 1548–1559, 10.1111/1462-2920.12577

1490 Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium A. Liaimer, E. J. N. Helfrich, K. Hinrichs, A. Guljamow, K. Ishida, C. Hertweck, E. Dittmann Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences 2015, 112, 1862–1867, 10.1073/pnas.1419543112

1482 Combined Electrochemistry and Surface-Enhanced Infrared Absorption Spectroscopy of Gramicidin A Incorporated into Tethered Bilayer Lipid Membranes J. Kozuch, C. Steinem, P. Hildebrandt, D. Millo Angewandte Chemie International Edition 2012, 51, 8114–8117, 10.1002/anie.201203214

1473 Voltage-dependent structural changes of the membrane-bound anion channel hVDAC1 probed by SEIRA and electrochemical impedance spectroscopy J. Kozuch, C. Weichbrodt, D. Millo, K. Giller, S. Becker, P. Hildebrandt, C. Steinem Phys. Chem. Chem. Phys. 2014, 16, 9546–9555, 10.1039/C4CP00167B

1467 Controlling fertilization and cAMP signaling in sperm by optogenetics V. Jansen, L. Alvarez, M. Balbach, T. Strünker, P. Hegemann, U. B. Kaupp, D. Wachten eLife eLife 2015, 4, 10.7554/eLife.05161

1413 Die Struktur eines transienten Komplexes einer nicht-ribosomalen Peptidsynthetase mit einer P450-Monooxygenase K. Haslinger, C. Brieke, S. Uhlmann, L. Sieverling, R. D. Süssmuth, M. J. Cryle Angewandte Chemie 2014, 126, 8658–8662, 10.1002/ange.201404977

1412 The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase K. Haslinger, C. Brieke, S. Uhlmann, L. Sieverling, R. D. Süssmuth, M. J. Cryle Angewandte Chemie International Edition 2014, 53, 8518–8522, 10.1002/anie.201404977

1411 Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen S. Müller, E. Garcia-Gonzalez, A. Mainz, G. Hertlein, N. C. Heid, E. Mösker, H. van den Elst, H. S. Overkleeft, E. Genersch, R. D. Süssmuth Angewandte Chemie International Edition 2014, 53, 10821–10825, 10.1002/anie.201404572

1410 Isolation and structure elucidation of the nucleoside antibiotic strepturidin from Streptomyces albus DSM 40763 A. Pesic, B. Steinhaus, S. Kemper, J. Nachtigall, H. J. Kutzner, G. Höfle, R. D. Süssmuth The Journal of Antibiotics 2014, 67, 471–477, 10.1038/ja.2014.16

1409 Elucidation of sevadicin, a novel non-ribosomal peptide secondary metabolite produced by the honey bee pathogenic bacterium E. Garcia-Gonzalez, S. Müller, P. Ensle, R. D. Süssmuth, E. Genersch Environmental Microbiology Environmental Microbiology 2014, 16, 1297–1309, 10.1111/1462-2920.12417

1407 Biological effects of paenilamicin, a secondary metabolite antibiotic produced by the honey bee pathogenic bacterium E. Garcia-Gonzalez, S. Müller, G. Hertlein, N. Heid, R. D. Süssmuth, E. Genersch MicrobiologyOpen MicrobiologyOpen 2014, 3, 642–656, 10.1002/mbo3.195

1402 Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase C. Gasser, S. Taiber, C. M. Yeh, C. H. Wittig, P. Hegemann, S. Ryu, F. Wunder, A. Moglich Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences 2014, 111, 8803–8808, 10.1073/pnas.1321600111

1376 Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions A. R. Weiz, K. Ishida, F. Quitterer, S. Meyer, J. C. Kehr, K. M. Müller, M. Groll, C. Hertweck, E. Dittmann Angewandte Chemie International Edition 2014, 53, 3735–3738, 10.1002/anie.201309721

1358 A Photochromic Histidine Kinase Rhodopsin (HKR1) That Is Bimodally Switched by Ultraviolet and Blue Light M. Luck, T. Mathes, S. Bruun, R. Fudim, R. Hagedorn, T. M. Tran Nguyen, S. Kateriya, J. T. M. Kennis, P. Hildebrandt, P. Hegemann Journal of Biological Chemistry 2012, 287, 40083–40090, 10.1074/jbc.M112.401604

1355 Biophysical, Mutational, and Functional Investigation of the Chromophore-Binding Pocket of Light-Oxygen-Voltage Photoreceptors R. P. Diensthuber, C. Engelhard, N. Lemke, T. Gleichmann, R. Ohlendorf, R. Bittl, A. Möglich ACS Synthetic Biology ACS Synthetic Biology 2014, 3, 811–819, 10.1021/sb400205x

1340 PLP-dependent Enzymes: a Powerful Tool for Metabolic Synthesis of. Non-canonical Amino Acids M. Si Salvo, N. Budisa, R. Contestabile Beilstein Symposium on Molecular Engineering and Control M. G. Hicks and Kettner, C. Logos Verlag 2014,

1339 Expanded genetic code for the engineering of ribosomally synthetized and post-translationally modified peptide natural products (RiPPs) N. Budisa Current Opinion in Biotechnology 2013, 24, 591–598, 10.1016/j.copbio.2013.02.026

1338 Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments C. G. Acevedo-Rocha, M. G. Hoesl, S. Nehring, M. Royter, C. Wolschner, B. Wiltschi, G. Antranikian, N. Budisa Catalysis Science & Technology Catalysis Science & Technology 2013, 3, 1198– 10.1039/c3cy20712a

1335 Enhanced production of the nonribosomal peptide antibiotic valinomycin in Escherichia coli through small-scale high cell density fed-batch cultivation J. Li, J. Jaitzig, F. Hillig, R. Süssmuth, P. Neubauer Applied Microbiology and Biotechnology Applied Microbiology and Biotechnology 2013, 98, 591–601, 10.1007/s00253-013-5309-8

1334 Comparative investigations on thermostable pyrimidine nucleoside phosphorylases from Geobacillus thermoglucosidasius and Thermus thermophilus K. Szeker, X. Zhou, T. Schwab, A. Casanueva, D. Cowan, I. A. Mikhailopulo, P. Neubauer Journal of Molecular Catalysis B: Enzymatic 2012, 84, 27–34, 10.1016/j.molcatb.2012.02.006

1333 Recombinant purine nucleoside phosphorylases from thermophiles: preparation, properties and activity towards purine and pyrimidine nucleosides X. Zhou, K. Szeker, B. Janocha, T. Böhme, D. Albrecht, I. A. Mikhailopulo, P. Neubauer FEBS Journal 2013, 280, 1475–1490, 10.1111/febs.12143

1320 Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes J. C. Kehr, D. Gatte Picchi, E. Dittmann Beilstein Journal of Organic Chemistry 2011, 7, 1622–1635, 10.3762/bjoc.7.191

1319 Microcystin production revisited: conjugate formation makes a major contribution S. Meissner, J. Fastner, E. Dittmann Environmental Microbiology Environmental Microbiology 2013, 15, 1810–1820, 10.1111/1462-2920.12072

1318 Functional Analysis of Environmental DNA-Derived Microviridins Provides New Insights into the Diversity of the Tricyclic Peptide Family D. Gatte-Picchi, A. Weiz, K. Ishida, C. Hertweck, E. Dittmann Applied and Environmental Microbiology 2014, 80, 1380–1387, 10.1128/AEM.03502-13

1311 Cytochrome P450 Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis S. Uhlmann, R. D. Süssmuth, M. J. Cryle ACS Chemical Biology ACS Chemical Biology 2013, 8, 2586–2596, 10.1021/cb400555e

1310 Champacyclin, a New Cyclic Octapeptide from Streptomyces Strain C42 Isolated from the Baltic Sea A. Pesic, H. Baumann, K. Kleinschmidt, P. Ensle, J. Wiese, R. Süssmuth, J. Imhoff Marine Drugs Marine Drugs 2013, 11, 4834–4857, 10.3390/md11124834

1309 Arg-Thz is a minimal substrate for the Nα,Nα-arginyl methyltransferase involved in the biosynthesis of plantazolicin N. A. Piwowarska, S. Banala, H. S. Overkleeft, R. D. Süssmuth Chemical Communications 2013, 49, 10703– 10.1039/c3cc45898a

1308 Reconstituted Biosynthesis of the Nonribosomal Macrolactone Antibiotic Valinomycin in J. Jaitzig, J. Li, R. D. Süssmuth, P. Neubauer ACS Synthetic Biology ACS Synthetic Biology 2013, 3, 432–438, 10.1021/sb400082j

1299 Ein Mikrogelbaukasten für die bioorthogonale Verkapselung und pH-gesteuerte Freisetzung von lebenden Zellen D. Steinhilber, T. Rossow, S. Wedepohl, F. Paulus, S. Seiffert, R. Haag Angewandte Chemie 2013, 125, 13780–13785, 10.1002/ange.201308005

1298 A Microgel Construction Kit for Bioorthogonal Encapsulation and pH-Controlled Release of Living Cells D. Steinhilber, T. Rossow, S. Wedepohl, F. Paulus, S. Seiffert, R. Haag Angewandte Chemie International Edition 2013, 52, 13538–13543, 10.1002/anie.201308005

1287 Building photoswitchable 3,4\'-AMPB peptides: Probing chemical ligation methods with reducible azobenzene thioesters G. Zeyat, K. Rück-Braun Beilstein Journal of Organic Chemistry 2012, 8, 890–896, 10.3762/bjoc.8.101

1258 Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms O. P. Ernst, D. T. Lodowski, M. Elstner, P. Hegemann, L. S. Brown, H. Kandori Chemical Reviews Chemical Reviews 2013, 114, 126–163, 10.1021/cr4003769

1158 Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides M. Royer, R. Koebnik, M. Marguerettaz, V. Barbe, G. P. Robin, C. Brin, S. Carrere, C. Gomez, M. Hügelland, G. H. Völler, J. Noëll, I. Pieretti, S. Rausch, V. Verdier, S. Poussier, P. Rott, R. D. Süssmuth, S. Cociancich BMC Genomics BMC Genomics 2013, 14, 658– 10.1186/1471-2164-14-658

1156 Biotransformation of the Fungal Phytotoxin Fomannoxin by Soil Streptomycetes N. Horlacher, J. Nachtigall, D. Schulz, R. D. Süssmuth, R. Hampp, H. P. Fiedler, S. D. Schrey Journal of Chemical Ecology Journal of Chemical Ecology 2013, 39, 931–941, 10.1007/s10886-013-0290-3

1155 Involvement and Unusual Substrate Specificity of a Prolyl Oligopeptidase in Class III Lanthipeptide Maturation G. H. Völler, B. Krawczyk, P. Ensle, R. D. Süssmuth Journal of the American Chemical Society 2013, 135, 7426–7429, 10.1021/ja402296m

1150 The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications G. Férir, M. I. Petrova, G. Andrei, D. Huskens, B. Hoorelbeke, R. Snoeck, J. Vanderleyden, J. Balzarini, S. Bartoschek, M. Brönstrup, R. D. Süssmuth, D. Schols PLoS ONE 2013, 8, 10.1371/journal.pone.0064010

1135 Hybrid hierarchical patterns of gold nanoparticles and poly(ethylene glycol) microstructures J. Chen, M. Arafeh, A. Guiet, D. Felkel, A. Loebus, S. M. Kelleher, A. Fischer, M. C. Lensen Journal of Materials Chemistry C Journal of Materials Chemistry C 2013, 1, 7709– 10.1039/C3TC30811A

1122 P. Hegemann, S. Sigrist Optogenetics De Gruyter 2013,

1120 Towards an Understanding of Channelrhodopsin Function: Simulations Lead to Novel Insights of the Channel Mechanism H. C. Watanabe, K. Welke, D. J. Sindhikara, P. Hegemann, M. Elstner Journal of Molecular Biology 2013, 425, 1795–1814, 10.1016/j.jmb.2013.01.033

1119 Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics J. Akerboom, N. Carreras Calderón, L. Tian, S. Wabnig, M. Prigge, J. Tolö, A. Gordus, M. B. Orger, K. E. Severi, J. J. Macklin, R. Patel, S. R. Pulver, T. J. Wardill, E. Fischer, C. Schüler, T. W. Chen, K. S. Sarkisyan, J. S. Marvin, C. I. Bargmann, D. S. Kim, S. Kügler, L. Lagnado, P. Hegemann, A. Gottschalk, E. R. Schreiter, L. L. Looger Frontiers in Molecular Neuroscience Frontiers in Molecular Neuroscience 2013, 6, 10.3389/fnmol.2013.00002

1118 From channelrhodopsins to optogenetics P. Hegemann, G. Nagel EMBO Molecular Medicine EMBO Molecular Medicine 2013, 5, 173–176, 10.1002/emmm.201202387

1117 Optogenetic Modulation of an Adenylate Cyclase in Demonstrates a Requirement of the Parasite cAMP for Host-Cell Invasion and Stage Differentiation A. Hartmann, R. D. Arroyo-Olarte, K. Imkeller, P. Hegemann, R. Lucius, N. Gupta Journal of Biological Chemistry 2013, 288, 13705–13717, 10.1074/jbc.M113.465583

1081 Full-Length Structure of a Sensor Histidine Kinase Pinpoints Coaxial Coiled Coils as Signal Transducers and Modulators R. P. Diensthuber, M. Bommer, T. Gleichmann, A. Möglich Structure 2013, 21, 1127–1136, 10.1016/j.str.2013.04.024

1051 Resonance Raman and vibronic absorption spectra with Duschinsky rotation from a time-dependent perspective: Application to β-carotene S. Banerjee, D. Kröner, P. Saalfrank The Journal of Chemical Physics 2012, 137, 22– 10.1063/1.4748147

973 Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature P. G. Arnison, M. J. Bibb, G. Bierbaum, A. A. Bowers, T. S. Bugni, G. Bulaj, J. A. Camarero, D. J. Campopiano, G. L. Challis, J. Clardy, P. D. Cotter, D. J. Craik, M. Dawson, E. Dittmann, S. Donadio, P. C. Dorrestein, K. D. Entian, M. A. Fischbach, J. S. Garavelli, U. Göransson, C. W. Gruber, D. H. Haft, T. K. Hemscheidt, C. Hertweck, C. Hill, A. R. Horswill, M. Jaspars, W. L. Kelly, J. P. Klinman, O. P. Kuipers, A. J. Link, W. Liu, M. A. Marahiel, D. A. Mitchell, G. N. Moll, B. S. Moore, R. Müller, S. K. Nair, I. F. Nes, G. E. Norris, B. M. Olivera, H. Onaka, M. L. Patchett, J. Piel, M. J. T. Reaney, S. Rebuffat, R. P. Ross, H. G. Sahl, E. W. Schmidt, M. E. Selsted, K. Severinov, B. Shen, K. Sivonen, L. Smith, T. Stein, R. D. Süssmuth, J. R. Tagg, G. L. Tang, A. W. Truman, J. C. Vederas, C. T. Walsh, J. D. Walton, S. C. Wenzel, J. M. Willey, W. A. van der Donk Nat. Prod. Rep. 2013, 30, 108–160, 10.1039/c2np20085f

972 Cyanobacterial toxins: biosynthetic routes and evolutionary roots E. Dittmann, D. P. Fewer, B. A. Neilan FEMS Microbiology Reviews FEMS Microbiologial Reviews 2012, 10.1111/1574-6976.12000

971 Cyanobacteria as source for natural products M. Welker, E. Dittmann, H. von Döhren Methods Enzymol 2012, 517, 23–46, 10.1016/B978-0-12-404634-4.00002-4

931 Heterologous Expression and Engineering Studies of Labyrinthopeptins, Class III Lantibiotics from Actinomadura namibiensis J. M. Krawczyk, G. H. Völler, B. Krawczyk, J. Kretz, M. Brönstrup, R. D. Süssmuth Chemistry & Biology 2013, 20, 111–122, 10.1016/j.chembiol.2012.10.023

910 Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120 G. Férir, A. Hänchen, K. O. François, B. Hoorelbeke, D. Huskens, F. Dettner, R. D. Süssmuth, D. Schols Virology Virology 2012, 433, 308–319, 10.1016/j.virol.2012.08.007

909 Curvopeptin: A New Lanthionine-Containing Class III Lantibiotic and its Co-substrate Promiscuous Synthetase B. Krawczyk, G. H. Völler, J. Völler, P. Ensle, R. D. Süssmuth ChemBioChem 2012, 13, 2065–2071, 10.1002/cbic.201200417

907 Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392 D. Schulz, J. Nachtigall, U. Geisen, H. Kalthoff, J. F. Imhoff, H. P. Fiedler, R. D. Süssmuth The Journal of Antibiotics The Journal of Antibiotics 2012, 65, 369–372, 10.1038/ja.2012.33

905 In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues D. Matthes, L. Richter, J. Müller, A. Denisiuk, S. C. Feifel, Y. Xu, P. Espinosa-Artiles, R. D. Süssmuth, I. Molnár Chemical Communications 2012, 48, 5674– 10.1039/C2CC31669B

873 Parallel reactor system for screening and characterisation of biocatalysts E. Lyagin, A. Drews, M. Kraume Czasopismo Techniczne Mechanika 2012, 5, 149–154,

868 Vibrational Stark Effect of the Electric-Field Reporter 4-Mercaptobenzonitrile as a Tool for Investigating Electrostatics at Electrode/SAM/Solution Interfaces G. Schkolnik, J. Salewski, D. Millo, I. Zebger, S. Franzen, P. Hildebrandt International Journal of Molecular Sciences International Journal of Molecular Science 2012, 13, 7466–7482, 10.3390/ijms13067466

837 Characterization of New Class III Lantibiotics-Erythreapeptin, Avermipeptin and Griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus Demonstrates Stepwise N-Terminal Leader Processing G. H. Völler, J. M. Krawczyk, A. Pesic, B. Krawczyk, J. Nachtigall, R. D. Süssmuth ChemBioChem 2012, 13, 1174–1183, 10.1002/cbic.201200118

836 Congeneric Lantibiotics from Ribosomal In Vivo Peptide Synthesis with Noncanonical Amino Acids F. Oldach, R. Al Toma, A. Kuthning, T. Caetano, S. Mendo, N. Budisa, R. D. Süssmuth Angewandte Chemie International Edition 2012, 51, 415–418, 10.1002/anie.201106154

805 Coupling of Ci-VSP Modules Requires a Combination of Structure and Electrostatics within the Linker K. Hobiger, T. Utesch, M. A. Mroginski, T. Friedrich Biophysical Journal 2012, 102, 1313–1322, 10.1016/j.bpj.2012.02.027

803 Control of Gastric H,K-ATPase Activity by Cations, Voltage and Intracellular pH Analyzed by Voltage Clamp Fluorometry in Xenopus Oocytes K. L. Dürr, N. N. Tavraz, T. Friedrich PLoS ONE 2012, 7, 10.1371/journal.pone.0033645

800 Mapping local electric fields in proteins at biomimetic interfaces G. Schkolnik, T. Utesch, J. Salewski, K. Tenger, D. Millo, A. Kranich, I. Zebger, C. Schulz, L. Zimányi, G. Rákhely, M. A. Mroginski, P. Hildebrandt Chem. Commun. 2012, 48, 70–72, 10.1039/c1cc13186a

670 Non-adiabatic excited state dynamics of riboflavin after photoexcitation B. Klaumünzer, D. Kröner, H. Lischka, P. Saalfrank Physical Chemistry Chemical Physics 2012, 14, 8693– 10.1039/C2CP40978J

417 BLUF Hydrogen network dynamics and UV/Vis spectra: A combined molecular dynamics and quantum chemical study J. P. Götze, C. Greco, R. Mitrić, V. Bonačić-Koutecký, P. Saalfrank Journal of Computational Chemistry Journal of Photochemistry and Photobiology B: Biology 2012, 33, 2233–2242, 10.1002/jcc.23056