Prof. Dr. Roderich Süssmuth - Publications

2428 Combined venom profiling and cytotoxicity screening of the Radde's mountain viper ( Montivipera raddei ) and Mount Bulgar Viper ( Montivipera bulgardaghica ) with potent cytotoxicity against human A549 lung carcinoma cells A. Nalbantsoy, B. F. Hempel, D. Petras, P. Heiss, B. Göçmen, N. Iğci, M. Z. Yildiz, R. D. Süssmuth Toxicon 2017, 135, 71–83, 10.1016/j.toxicon.2017.06.008

2427 The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms S. Ainsworth, D. Petras, M. Engmark, R. D. Süssmuth, G. Whiteley, L. O. Albulescu, T. D. Kazandjian, S. C. Wagstaff, P. Rowley, W. Wüster, P. C. Dorrestein, A. S. Arias, J. M. Gutiérrez, R. A. Harrison, N. R. Casewell, J. J. Calvete Journal of Proteomics 2018, 172, 173–189, 10.1016/j.jprot.2017.08.016

2318 Phylogenomic Analysis of the Microviridin Biosynthetic Pathway Coupled with Targeted Chemo-Enzymatic Synthesis Yields Potent Protease Inhibitors M. N. Ahmed, E. Reyna-González, B. Schmid, V. Wiebach, R. D. Süssmuth, E. Dittmann, D. P. Fewer ACS Chemical Biology 2017, 12, 1538–1546, 10.1021/acschembio.7b00124

2317 Prerequisites of Isopeptide Bond Formation in Microcystin Biosynthesis S. Meyer, A. Mainz, J. C. Kehr, R. D. Süssmuth, E. Dittmann ChemBioChem 2017, 18, 2376–2379, 10.1002/cbic.201700389

2316 Correction to: Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides S. Boecker, S. Grätz, D. Kerwat, L. Adam, D. Schirmer, L. Richter, T. Schütze, D. Petras, R. D. Süssmuth, V. Meyer Fungal Biology and Biotechnology 2018, 5, 10.1186/s40694-018-0051-8

2008 TheO-Carbamoyl-Transferase Alb15 Is Responsible for the Modification of Albicidin D. Petras, D. Kerwat, A. Pesic, B. F. Hempel, L. von Eckardstein, S. Semsary, J. Arasté, M. Marguerettaz, M. Royer, S. Cociancich, R. D. Süssmuth ACS Chemical Biology 2016, 11, 1198–1204, 10.1021/acschembio.5b01001

2007 Top-down venomics of the East African green mamba, Dendroaspis angusticeps, and the black mamba, Dendroaspis polylepis, highlight the complexity of their toxin arsenals D. Petras, P. Heiss, R. A. Harrison, R. D. Süssmuth, J. J. Calvete Journal of Proteomics 2016, 146, 148–164, 10.1016/j.jprot.2016.06.018

2006 Leader Peptide-Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease-Targeted Libraries E. Reyna-González, B. Schmid, D. Petras, R. D. Süssmuth, E. Dittmann Angewandte Chemie 2016, 128, 9544–9547, 10.1002/ange.201604345

2005 Towards Biocontained Cell Factories: An Evolutionarily Adapted Escherichia coli Strain Produces a New-to-nature Bioactive Lantibiotic Containing Thienopyrrole-Alanine A. Kuthning, P. Durkin, S. Oehm, M. G. Hoesl, N. Budisa, R. D. Süssmuth Scientific Reports 2016, 6, 33447– 10.1038/srep33447

1919 Leader Peptide-Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease-Targeted Libraries E. Reyna-González, B. Schmid, D. Petras, R. D. Süssmuth, E. Dittmann Angewandte Chemie International Edition 2016, 55, 9398–9401, 10.1002/anie.201604345

1907 Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS S. Meyer, J. C. Kehr, A. Mainz, D. Dehm, D. Petras, R. Süssmuth, E. Dittmann Cell Chemical Biology 2016, 23, 462–471, 10.1016/j.chembiol.2016.03.011

1827 Rational biosynthetic approaches for the production of new-to-nature compounds in fungi S. Boecker, S. Zobel, V. Meyer, R. D. Süssmuth Fungal Genetics and Biology 2016, 10.1016/j.fgb.2016.02.003

1813 Mass spectrometry guided venom profiling and bioactivity screening of the Anatolian Meadow Viper, Vipera anatolica B. Göçmen, P. Heiss, D. Petras, A. Nalbantsoy, R. D. Süssmuth Toxicon 2015, 107, 163–174, 10.1016/j.toxicon.2015.09.013

1812 Streptocollin, a Type IV Lanthipeptide Produced by Streptomyces collinus Tü 365 D. Iftime, M. Jasyk, A. Kulik, J. F. Imhoff, E. Stegmann, W. Wohlleben, R. D. Süssmuth, T. Weber ChemBioChem 2015, 16, 2615–2623, 10.1002/cbic.201500377

1811 The Supersized Class III Lanthipeptide Stackepeptin Displays Motif Multiplication in the Core Peptide N. A. Jungmann, E. F. van Herwerden, M. Hügelland, R. D. Süssmuth ACS Chemical Biology 2016, 11, 69–76, 10.1021/acschembio.5b00651

1810 Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism M. Gonsior, A. Mühlenweg, M. Tietzmann, S. Rausch, A. Poch, R. D. Süssmuth ChemBioChem 2015, 16, 2610–2614, 10.1002/cbic.201500432

1809 Reprogramming the Biosynthesis of Cyclodepsipeptide Synthetases to Obtain New Enniatins and Beauvericins S. Zobel, S. Boecker, D. Kulke, D. Heimbach, V. Meyer, R. D. Süssmuth ChemBioChem 2016, 17, 283–287, 10.1002/cbic.201500649

1714 Minimum information about a biosynthetic gene cluster M. H. Medema, R. Kottmann, P. Yilmaz, R. Süssmuth, and coworkers Nature Chemical Biology 2015, 11, 625–631, 10.1038/nchembio.1890

1705 Venom Proteomics of Indonesian King Cobra, Ophiophagus hannah : Integrating Top-Down and Bottom-Up Approaches D. Petras, P. Heiss, R. D. Süssmuth, J. J. Calvete Journal of Proteome Research 2015, 14, 2539–2556, 10.1021/acs.jproteome.5b00305

1704 Lipocarbazole, an efficient lipid peroxidation inhibitor anchored in the membrane G. Fabre, A. Hänchen, C. A. Calliste, K. Berka, S. Banala, M. Otyepka, R. D. Süssmuth, P. Trouillas Bioorganic & Medicinal Chemistry 2015, 23, 4866–4870, 10.1016/j.bmc.2015.05.031

1703 The Albicidin Resistance Factor AlbD Is a Serine Endopeptidase That Hydrolyzes Unusual Oligoaromatic-Type Peptides L. Vieweg, J. Kretz, A. Pesic, D. Kerwat, S. Grätz, M. Royer, S. Cociancich, A. Mainz, R. D. Süssmuth Journal of the American Chemical Society 2015, 137, 7608–7611, 10.1021/jacs.5b04099

1702 Scale-up bioprocess development for production of the antibiotic valinomycin in Escherichia coli based on consistent fed-batch cultivations J. Li, J. Jaitzig, P. Lu, R. D. Süssmuth, P. Neubauer Microbial Cell Factories 2015, 14, 10.1186/s12934-015-0272-y

1560 The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo R. Dornetshuber-Fleiss, D. Heilos, T. Mohr, L. Richter, R. D. Süssmuth, M. Zlesak, A. Novicky, P. Heffeter, R. Lemmens-Gruber, W. Berger Biochemical Pharmacology 2015, 93, 318–331, 10.1016/j.bcp.2014.12.013

1559 The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine S. Cociancich, A. Pesic, D. Petras, S. Uhlmann, J. Kretz, V. Schubert, L. Vieweg, S. Duplan, M. Marguerettaz, J. Noëll, I. Pieretti, M. Hügelland, S. Kemper, A. Mainz, P. Rott, M. Royer, R. D. Süssmuth Nature Chemical Biology 2015, 10.1038/nchembio.1734

1558 Production of the Catechol Type Siderophore Bacillibactin by the Honey Bee Pathogen Paenibacillus larvae G. Hertlein, S. Müller, E. Garcia-Gonzalez, L. Poppinga, R. D. Süssmuth, E. Genersch, W. Blenau PLoS ONE 2014, 9, 10.1371/journal.pone.0108272

1554 Totalsynthese von Albicidin - eine Leitstruktur aus Xanthomonas albilineans fuer potente antibakterielle Gyrase-Inhibitoren J. Kretz, D. Kerwat, V. Schubert, S. Grätz, A. Pesic, S. Semsary, S. Cociancich, M. Royer, R. D. Süssmuth Angewandte Chemie 2015, 127, 1992–1996, 10.1002/ange.201409584

1553 Total Synthesis of Albicidin: A Lead Structure from Xanthomonas albilineans for Potent Antibacterial Gyrase Inhibitors J. Kretz, D. Kerwat, V. Schubert, S. Grätz, A. Pesic, S. Semsary, S. Cociancich, M. Royer, R. D. Süssmuth Angewandte Chemie International Edition 2015, 54, 1969–1973, 10.1002/anie.201409584

1552 Site-Directed and Global Incorporation of Orthogonal and Isostructural Noncanonical Amino Acids into the Ribosomal Lasso Peptide Capistruin R. S. Al Toma, A. Kuthning, M. P. Exner, A. Denisiuk, J. Ziegler, N. Budisa, R. D. Süssmuth ChemBioChem 2015, 16, 503–509, 10.1002/cbic.201402558

1551 Bacillus subtilis as heterologous host for the secretory production of the non-ribosomal cyclodepsipeptide enniatin S. Zobel, J. Kumpfmüller, R. D. Süssmuth, T. Schweder Applied Microbiology and Biotechnology 2014, 99, 681–691, 10.1007/s00253-014-6199-0

1549 Dissecting Reactions of Nonlinear Precursor Peptide Processing of the Class III Lanthipeptide Curvopeptin N. A. Jungmann, B. Krawczyk, M. Tietzmann, P. Ensle, R. D. Süssmuth Journal of the American Chemical Society 2014, 136, 15222–15228, 10.1021/ja5062054

1534 Type II thioesterase improves heterologous biosynthesis of valinomycin in Escherichia coli J. Li, J. Jaitzig, L. Theuer, O. E. Legala, R. D. Süssmuth, P. Neubauer Journal of Biotechnology 2015, 193, 16–22, 10.1016/j.jbiotec.2014.10.037

1413 Die Struktur eines transienten Komplexes einer nicht-ribosomalen Peptidsynthetase mit einer P450-Monooxygenase K. Haslinger, C. Brieke, S. Uhlmann, L. Sieverling, R. D. Süssmuth, M. J. Cryle Angewandte Chemie 2014, 126, 8658–8662, 10.1002/ange.201404977

1412 The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase K. Haslinger, C. Brieke, S. Uhlmann, L. Sieverling, R. D. Süssmuth, M. J. Cryle Angewandte Chemie International Edition 2014, 53, 8518–8522, 10.1002/anie.201404977

1411 Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae S. Müller, E. Garcia-Gonzalez, A. Mainz, G. Hertlein, N. C. Heid, E. Mösker, H. van den Elst, H. S. Overkleeft, E. Genersch, R. D. Süssmuth Angewandte Chemie International Edition 2014, 10.1002/anie.201404572

1410 Isolation and structure elucidation of the nucleoside antibiotic strepturidin from Streptomyces albus DSM 40763 A. Pesic, B. Steinhaus, S. Kemper, J. Nachtigall, H. J. Kutzner, G. Höfle, R. D. Süssmuth The Journal of Antibiotics 2014, 67, 471–477, 10.1038/ja.2014.16

1409 Elucidation of sevadicin, a novel non-ribosomal peptide secondary metabolite produced by the honey bee pathogenic bacterium Paenibacillus larvae E. Garcia-Gonzalez, S. Müller, P. Ensle, R. D. Süssmuth, E. Genersch Environmental Microbiology 2014, 16, 1297–1309, 10.1111/1462-2920.12417

1408 Stereochemistry and Conformation of Skyllamycin, a Non-Ribosomally Synthesized Peptide from Streptomyces sp. Acta 2897 V. Schubert, F. Di Meo, P. L. Saaidi, S. Bartoschek, H. P. Fiedler, P. Trouillas, R. D. Süssmuth Chemistry - A European Journal 2014, 20, 4948–4955, 10.1002/chem.201304562

1407 Biological effects of paenilamicin, a secondary metabolite antibiotic produced by the honey bee pathogenic bacterium Paenibacillus larvae E. Garcia-Gonzalez, S. Müller, G. Hertlein, N. Heid, R. D. Süssmuth, E. Genersch MicrobiologyOpen 2014, 10.1002/mbo3.195

1335 Enhanced production of the nonribosomal peptide antibiotic valinomycin in Escherichia coli through small-scale high cell density fed-batch cultivation J. Li, J. Jaitzig, F. Hillig, R. Süssmuth, P. Neubauer Applied Microbiology and Biotechnology 2013, 98, 591–601, 10.1007/s00253-013-5309-8

1311 Cytochrome P450 Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis S. Uhlmann, R. D. Süssmuth, M. J. Cryle ACS Chemical Biology 2013, 8, 2586–2596, 10.1021/cb400555e

1310 Champacyclin, a New Cyclic Octapeptide from Streptomyces Strain C42 Isolated from the Baltic Sea A. Pesic, H. Baumann, K. Kleinschmidt, P. Ensle, J. Wiese, R. Süssmuth, J. Imhoff Marine Drugs 2013, 11, 4834–4857, 10.3390/md11124834

1309 Arg-Thz is a minimal substrate for the Nα,Nα-arginyl methyltransferase involved in the biosynthesis of plantazolicin N. A. Piwowarska, S. Banala, H. S. Overkleeft, R. D. Süssmuth Chemical Communications 2013, 49, 10703–10705, 10.1039/c3cc45898a

1308 Reconstituted Biosynthesis of the Nonribosomal Macrolactone Antibiotic Valinomycin in J. Jaitzig, J. Li, R. D. Süssmuth, P. Neubauer ACS Synthetic Biology 2013, 131218130145008– 10.1021/sb400082j

1158 Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides M. Royer, R. Koebnik, M. Marguerettaz, V. Barbe, G. P. Robin, C. Brin, S. Carrere, C. Gomez, M. Hügelland, G. H. Völler, J. Noëll, I. Pieretti, S. Rausch, V. Verdier, S. Poussier, P. Rott, R. D. Süssmuth, S. Cociancich BMC Genomics 2013, 14, 658– 10.1186/1471-2164-14-658

1157 Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides B. Krawczyk, E. F. van Herwerden, H. S. Overkleeft, R. D. Süssmuth Angewandte Chemie International Edition 2013, 52, 9082–9084, 10.1002/anie.201304851

1156 Biotransformation of the Fungal Phytotoxin Fomannoxin by Soil Streptomycetes N. Horlacher, J. Nachtigall, D. Schulz, R. D. Süssmuth, R. Hampp, H. P. Fiedler, S. D. Schrey Journal of Chemical Ecology 2013, 39, 931–941, 10.1007/s10886-013-0290-3

1155 Involvement and Unusual Substrate Specificity of a Prolyl Oligopeptidase in Class III Lanthipeptide Maturation G. H. Völler, B. Krawczyk, P. Ensle, R. D. Süssmuth Journal of the American Chemical Society 2013, 135, 7426–7429, 10.1021/ja402296m

1154 Conformational investigation of antibiotic proximicin by X-ray structure analysis and quantum studies suggest a stretched conformation of this type of γ-peptide A. Denisiuk, V. Schubert, F. E. Wolter, E. Irran, P. Trouillas, R. D. Süssmuth Bioorganic & Medicinal Chemistry 2013, 21, 3582–3589, 10.1016/j.bmc.2013.02.051

1153 Alanine Scan of the Peptide Antibiotic Feglymycin: Assessment of Amino Acid Side Chains Contributing to Antimicrobial Activity A. Hänchen, S. Rausch, B. Landmann, L. Toti, A. Nusser, R. D. Süssmuth ChemBioChem 2013, 14, 625–632, 10.1002/cbic.201300032

1152 Characterization of the Biosynthetic Genes for 10,11-Dehydrocurvularin, a Heat Shock Response-Modulating Anticancer Fungal Polyketide from Aspergillus terreus Y. Xu, P. Espinosa-Artiles, V. Schubert, Y. M. Xu, W. Zhang, M. Lin, A. A. L. Gunatilaka, R. Sussmuth, I. Molnar Applied and Environmental Microbiology 2013, 79, 2038–2047, 10.1128/AEM.03334-12

1151 Total Synthesis of the Ribosomally Synthesized Linear Azole-Containing Peptide Plantazolicin A from Bacillus amyloliquefaciens S. Banala, P. Ensle, R. D. Süssmuth Angewandte Chemie International Edition 2013, 52, 9518–9523, 10.1002/anie.201302266

1150 The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications G. Férir, M. I. Petrova, G. Andrei, D. Huskens, B. Hoorelbeke, R. Snoeck, J. Vanderleyden, J. Balzarini, S. Bartoschek, M. Brönstrup, R. D. Süssmuth, D. Schols, H. Favoreel PLoS ONE 2013, 8, 10.1371/journal.pone.0064010

973 Ribosomally synthesized and posttranslationally modified natural products: overview and recommendations for a universal nomenclature E. Dittmann, R. Süssmuth Natural Product Reports 2013, 30, 108–160, 10.1039/c2np20085f

931 Heterologous expression and engineering studies of labyrinthopeptins, new class III lantibiotics from Actinomadura namibiensis J. M. Krawczyk, G. H. Völler, B. Krawczyk, J. Kretz, M. Broenstrup, R. D. Süssmuth Chemistry & Biology 2013, 20, 111–122, 10.1016/j.chembiol.2012.10.023

910 Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120 G. Ferir, A. Hänchen, K. O. Francois, B. Hoorelbeke, D. Huskens, F. Dettner, R. D. Süssmuth, D. Schols Virology 2012, 433, 308–319, 10.1016/j.virol.2012.08.007

909 Curvopeptin: a new lanthionine-containing class III lantibiotic and its co-substrate promiscuous synthetase B. Krawczyk, G. H. Völler, J. Völler, P. Ensle, R. D. Süssmuth ChemBioChem 2012, 13, 2065–2071, 10.1002/cbic.201200417

908 Deuterium labeled peptides give insights into the directionality of class III lantibiotic synthetase LabKC B. Krawczyk, P. Ensle, W. Müller, R. D. Süssmuth Journal of the American Chemical Society 2012, 134, 9922–9925, 10.1021/ja3040224

907 Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392* D. Schulz, J. Nachtigall, U. Geisen, H. Kalthoff, J. F. Imhoff, H. P. Fiedler, R. D. Süssmuth The Journal of Antibiotics 2012, 65, 369–372, 10.1038/ja.2012.33

905 In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues D. Matthes, L. Richter, J. Müller, A. Denisiuk, S. C. Feifel, Y. Xu, P. Espinosa-Artiles, R. D. Süssmuth, I. Molnar Chemical Communications 2012, 48, 5674–5676, 10.1039/C2CC31669B

837 Characterization of New Class III Lantibiotics-Erythreapeptin, Avermipeptin and Griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus Demonstrates Stepwise N-Terminal Leader Processing G. H. Völler, J. M. Krawczyk, A. Pesic, B. Krawczyk, J. Nachtigall, R. D. Süssmuth ChemBioChem 2012, 13, 1174–1183, 10.1002/cbic.201200118

836 Congeneric Lantibiotics from Ribosomal In Vivo Peptide Synthesis with Noncanonical Amino Acids** F. Oldach, R. Al Toma, A. Kuthning, T. Caetano, S. Mendo, N. Budisa, R. Süssmuth Angewandte Chemie International Edition 2012, 51, 415–418, 10.1002/anie.201106154

749 Biosynthetic gene cluster of the non-ribosomally synthesized cyclodepsipeptide skyllamycin: Deciphering unprecedented ways of unusual hydroxylation reactions S. Pohle, C. Appelt, M. Roux, H. P. Fiedler, R. D. Süssmuth Journal of the American Chemical Society 2011, 133, 6194–6205, 10.1021/ja108971p

748 Plantazolicin A and B: Structure elucidation of ribosomally synthesized thiazole/oxazole peptides from Bacillus amyloliquefaciens FZB42 B. Kalyon, S. Helaly, R. Scholz, J. Nachtigall, J. Vater, R. Borriss, R. D. Süssmuth Organic Letters 2011, 13, 2996–2999, 10.1021/ol200809m

747 Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan bio-synthesis pathway S. Rausch, A. Hänchen, A. Denisiuk, M. Löhken, T. Schneider, R. D. Süssmuth ChemBioChem 2011, 12, 1171–1173, 10.1002/cbic.201100120

746 Abyssomicin biosynthesis: Formation of an unusual polyketide antibiotic - feeding studies and genetic analysis E. M. Gottardi, J. M. Krawczyk, H. von Suchodoletz, S. Schadt, A. Mühlenweg, G. C. Uguru, S. Pelzer, H. P. Fiedler, M. J. Bibb, J. E. M. Stach, R. D. Süssmuth ChemBioChem 2011, 12, 1401–1410, 10.1002/cbic.201100172

745 Atacamycins A-C, 22-membered antitumor macrolactones produces by Streptomyces sp. C38 J. Nachtigall, A. Kulik, S. Helaly, A. T. Bull, M. Goodfellow, J. A. Asenjo, A. Maier, J. Wiese, J. F. Imhoff, R. D. Süssmuth, H. P. Fiedler The Journal of Antibiotics 2011, 10.1038/ja.2011.96

744 Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC W. M. Müller, P. Ensle, B. Krawczyk, R. D. Süssmuth Biochemistry 2011, 50, 8362–8373, 10.1021/bi200526q

743 Lichenicidin biosynthesis in Escherichia coli: licFGEHI immunity genes are not essential for lantibiotic production or self-protection T. Caetano, J. M. Krawczyk, E. Mösker, S. Mendo, R. D. Süssmuth Applied and Environmental Microbiology 2011, 5023–5026, 10.1128/AEM.00270-11

531 Fungal cyclooligomer depsipeptides: From classical biochemistry to combinatorial biosynthesis J. Müller, H. von Döhren, I. Molnar, R. D. Süssmuth Natural Product Reports 2011, 28, 99–124, 10.1039/C001463J

487 Aromatic C-methyltransferases with antipodal stereoselectivity for structurally diverse phenolic amino acids catalyze the methylation step in the biosynthesis of the actinomycin chromophor I. Crnovcic, R. D. Süssmuth, U. Keller Biochemistry 2010, 49, 9698–9705, 10.1021/bi101422r

486 Heterologous expression, biosynthesis and mutagenesis of type II lantibiotics from bacillus licheniformis in escherichia coli T. Caetano, J. M. Krawczyk, E. Mösker, R. D. Süssmuth, S. Mendo Chemistry & Biology 2011, 18, 90–100, 10.1016/j.chembiol.2010.11.010

485 Elaiomycins B and C: Alkylhydrazide Antibiotics from Streptomyces sp. BK 190 S. E. Helaly, A. Pesic , H. P. Fiedler, R. D. Süssmuth Organic Letters 2011, 13, 1052–1055, 10.1021/ol1031014

484 Thioamides in Nature: In Search of Secondary Metabolites in Anaerobic Microorganisms S. Banala, R. D. Süssmuth ChemBioChem 2010, 11, 1335–1337, 10.1002/cbic.201000266

389 In Vitro Synthesis of New Enniatins: Probing the alpha-D-Hydroxy Carboxylic Acid Binding Pocket of the Multienzyme Enniatin Synthetase S. C. Feifel, T. Schmiederer, T. Hornbogen, H. Berg, R. Zocher, R. D. Süssmuth ChemBioChem 2007, 8, 1767–1770, 10.1002/cbic.200700377

316 In vitro Biosynthesis of the Propeptide of Type-II Lantibiotic Labyrinthopeptin A2 Forming a C-C-Bond as a Novel Post-Translational Modification W. M. Müller, T. Schmiederer, P. Ensle, R. D. Süssmuth Angewandte Chemie International Edition 2010, 49, 2436–2440, 10.1002/anie.200905909

314 Total Synthesis of new lipocarbazoles isolated from the Actinomycete Tsukamurella pseudospumae Acta 1857 A. Hänchen, R. D. Süssmuth Synlett 2009, 15, 2483–2486, 10.1055/s-0029-1217815

312 Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity F. E. Wolter, L. Molinari, E. R. Socher, K. Schneider, G. Nicholson, W. Beil, O. Seitz, R. D. Süssmuth Bioorganic & Medicinal Chemistry Letters 2009, 19, 3811–3815, 10.1016/j.bmcl.2009.04.042

8 Module Extension of a Non-Ribosomal Peptide Synthetase of the Glycopeptide Antibiotic Balhimycin Produced by Amycolatopsis balhimycina D. Butz, T. Schmiederer, B. Hadatsch, W. Wohlleben, T. Weber, R. D. Süssmuth Chemistry - A European Journal 2008, 9, 1195–1200, 10.1002/cbic.200800068

7 In vitro Synthesis of New Cyclodepsipeptides of the PF1022-Type: Probing the alpha-D-Hydroxy Acid Tolerance of PF1022 Synthetase J. Müller, S. C. Feifel, T. Schmiederer, R. Zocher, R. D. Süssmuth Chemistry - A European Journal 2009, 10, 323–328, 10.1002/cbic.200800539

6 2-Amino-2-deoxyisochorismate Is a Key Intermediate in Bacillus subtilis p-Aminobenzoic Acid Biosynthesis H. S. Schadt, S. Schadt, F. Oldach, R. D. Süssmuth Journal of the American Chemical Society 2009, 131, 3481–3483, 10.1021/ja809283u