Dr. Kylie A. Vincent

© TU Berlin / Pressestelle / Jacek Ruta

Oxford University,

Clara Immerwahr Awardee 2012

Academic Background

Dr. Vincent holds a Bachelor of Arts (English Literature) and  Bachelor of Science (Hons, Chemistry/Biochemistry) from the University of Melbourne, Australia (2000). Her PhD (Chemistry, University of Melbourne, Australia, 2003) involved a joint research project with the John Innes Centre, Norwich, UK. She then took up a Postdoctoral Research position in the Inorganic Chemistry Laboratory, University of Oxford in 2002, and an RJP Williams Junior Research Fellowship at Wadham College in 2003. In 2007 she took up a Royal Society University Research Fellowship in the Inorganic Chemistry Laboratory, University of Oxford, and a Senior Research Fellowship at Wadham College, Oxford before joining Jesus College in 2008.

Research Interests

Understanding biological redox catalysis - in particular the efficient oxidation or production of hydrogen by microbial hydrogenase enzymes at [FeFe] or [NiFe] centres; studying enzyme active sites during catalytic turnover using direct electrochemical and Infrared spectro- electrochemical methods; exploiting enzyme catalysis in energy cycling.

UniCat publications

2019 Enzymes as modular catalysts for redox half-reactions in H2-powered chemical synthesis: from biology to technology H. A. Reeve, P. A. Ash, H. Park, A. Huang, M. Posidias, C. Tomlinson, O. Lenz, K. A. Vincent Biochemical Journal 2017, 474, 215–230, 10.1042/BCJ20160513

1782 Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling H. A. Reeve, L. Lauterbach, O. Lenz, K. A. Vincent ChemCatChem 2015, 7, 3480–3487, 10.1002/cctc.201500766

1779 Electrochemical and Infrared Spectroscopic Studies Provide Insight into Reactions of the NiFe Regulatory Hydrogenase from Ralstonia eutropha with O2 and CO P. A. Ash, J. Liu, N. Coutard, N. Heidary, M. Horch, I. Gudim, T. Simler, I. Zebger, O. Lenz, K. A. Vincent The Journal of Physical Chemistry B 2015, 119, 13807–13815, 10.1021/acs.jpcb.5b04164

1165 Attenuated total reflectance infrared spectroelectrochemistry at a carbon particle electrode; unmediated redox control of a [NiFe]-hydrogenase solution A. J. Healy, P. A. Ash, O. Lenz, K. A. Vincent Physical Chemistry Chemical Physics 2013, 15, 7055– 10.1039/c3cp00119a

1163 H2-driven cofactor regeneration with NAD(P)+-reducing hydrogenases L. Lauterbach, O. Lenz, K. A. Vincent FEBS Journal 2013, 280, 3058–3068, 10.1111/febs.12245

782 A modular system for regeneration of NAD cofactors using graphite particles modified with hydrogenase and diaphorase moieties H. A. Reeve, L. Lauterbach, P. A. Ash, O. Lenz, K. A. Vincent Chemical Communications 2012, 48, 1589–1591, 10.1039/C1CC14826E

763 Catalytic Properties of the Isolated Diaphorase Fragment of the NAD+-Reducing [NiFe]-Hydrogenase from Ralstonia eutropha L. Lauterbach, Z. Idris, K. A. Vincent, O. Lenz PLoS ONE 2011, 6, 10.1371/journal.pone.0025939

458 The Hydrogenase Subcomplex of the NAD+-Reducing [NiFe] Hydrogenase from Ralstonia eutropha - Insights into Catalysis and Redox Interconversions L. Lauterbach, J. Liu, M. Horch, P. Hummel, A. Schwarze, M. Haumann, K. A. Vincent, O. Lenz, I. Zebger European Journal of Inorganic Chemistry 2011, 7, 1067–1079, 10.1002/ejic.201001053

382 How oxygen attacks [FeFe] hydrogenases from photosynthetic organisms S. Stripp, G. Goldet, C. Brandmayr, O. Sanganas, K. A. Vincent, M. Haumann, F. A. Armstrong, T. Happe Proceedings of the National Academy of Sciences of the United States of America 2009, 106, 17331–17336, 10.1073/pnas.0905343106

136 Enzymatic oxidation of H2 in atmospheric O2: The electrochemistry of energy generation from trace H2 by aerobic by aerobic microorganisms J. A. Cracknell, K. A. Vincent, M. Ludwig, O. Lenz, B. Friedrich, F. A. Armstrong Journal of the American Chemical Society 2008, 130, 424–425, 10.1021/ja078299

135 Hydrogen production under aerobic conditions by membrane-bound hydrogenases from Ralstonia species G. Goldet, A. F. Wait, J. A. Cracknell, K. A. Vincent, M. Ludwig, O. Lenz, B. Friedrich, F. A. Armstrong Journal of the American Chemical Society 2008, 130, 11106–11113, 10.1021/ja8027668

131 Oxygen-tolerant H2 oxidation by membrane-bound [NiFe]-hydrogenase of Ralstonia species: Coping with low-level H2 in air M. Ludwig, J. A. Cracknell, K. A. Vincent, F. A. Armstrong, O. Lenz The Journal Of Biological Chemistry 2009, 284, 465–477, 10.1074/jbc.M803676200

The Clara Immerwahr Award 2012 was sponsored by